I have asked many people, some have said yes others have said no. I know you aren't allowed to be on anti depressants but that's not what I'm asking. When I piss in a cup, will it come back saying positive for zoloft? Regardless, the test would have to be very specific for the metabolites of sertraline itself, as serotonin is native to the body. Many websites I've visited have a list of what they test for and Zoloft wasn't among them. And thus you'd then have to test for every SSRI, SNRI, or MAOI out there. To be honest, I have no idea about anything in the military, nor do they teach us that. I was just going on the COMMON SENSE that a test for that drug would be highly unlikely. 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So let’s take a look at what Zoloft is, how it works, and the fascinating point I’ve found around whether it’s the right first choice for people suffering with anxiety. Zoloft belongs to a group of antidepressants known as selective serotonin re-uptake inhibitors, usually referred to as SSRI’s. This group of antidepressants works by balancing the body’s absorption of serotonin in the brain. It slows it down so that mood remains more consistent and positive. Clinical toxicology testing helps clinicians and case workers help patients by providing critical information about substances in a patient’s system. There are two main testing platforms: qualitative (meaning the test is either positive or negative) and quantitative (meaning the test measures drug concentration). Screening (also called “presumptive testing”) is a qualitative technique to identify certain targeted drugs. 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