The one where a sad little blob rolled around on screen with a rain cloud hovering over its head? That commercial first debuted back in 2001, and since then Zoloft, or Sertraline hydrochloride, has become one of the top psychiatric drugs used by American adults, according to one recent study. “Zoloft is one of the first-line antidepressant medications prescribed for both depression and anxiety, meaning it’s one of the most likely to work,” says Alison Hermann, M. D., a clinical psychiatrist at Weill Cornell Medicine and New York-Presbyterian Hospital. Zoloft is part of a class of drugs called SSRIs, or selective-serotonin reuptake inhibitors. “Their main effect has to do with changing the signaling of one of the main neurotransmitters in the brain, serotonin, which modulates mood,” explains James Murrough, M. D., the director of the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai. rogaine before and after Fw-300 #ya-qn-sort h2 /* Breadcrumb */ #ya-question-breadcrumb #ya-question-breadcrumb i #ya-question-breadcrumb a #bc .ya-q-full-text, .ya-q-text #ya-question-detail h1 html[lang="zh-Hant-TW"] .ya-q-full-text, html[lang="zh-Hant-TW"] .ya-q-text, html[lang="zh-Hant-HK"] .ya-q-full-text, html[lang="zh-Hant-HK"] .ya-q-text html[lang="zh-Hant-TW"] #ya-question-detail h1, html[lang="zh-Hant-HK"] #ya-question-detail h1 /* Trending Now */ /* Center Rail */ #ya-center-rail .profile-banner-default .ya-ba-title #Stencil . Bgc-lgr .tupwrap .comment-text /* Right Rail */ #Stencil . Fw-300 .qstn-title #ya-trending-questions-show-more, #ya-related-questions-show-more #ya-trending-questions-more, #ya-related-questions-more /* DMROS */ . Amoxicillin strep throat Diflucan interactions The Zoloft dosage that doctors usually recommend for adults with depression or obsessive-compulsive disorder is 50 mg once a day. Although the starting dose for people with panic disorder, post-traumatic stress disorder, or social anxiety disorder is typically 25 mg daily, healthcare providers often increase that dose to 50 mg daily. canada drug pharmacy FDA posted Advancing Health through Innovation New Drug Approvals and Other Drug Therapy Advances 2018, a summary of the Center for Drug Evaluation and Research’s CDER’s novel drugs and other notable drug therapy approvals of 2018. Zoloft is a super-common antidepressant and anti-anxiety medication, but there are some side effects you should be aware of. Murrough suggests starting on the lowest possible dose to avoid. It is not like one say the medicine is fine and the next day it goes bad. This medication takes up to 4 weeks to get to steady state. Over time a medication may gradually lose some of its potency but most likely Zoloft (sertraline) that is 6 months past the expiration date is still very potent and should still be as effective as if it was prior to the expiration date. Since you have such early positive effects, it would not be a bad idea to talk to your doctor about staying for another week at 25mg. 200 mg of Zoloft (sertraline) never killed anybody. Read more See 1 more doctor answer Not knowing your age, weight, other meds and health status, it is hard to say. How you are feeling in an important indicator to the meds effectiveness. Skipping tomorrow shouldn't disrupt the effect of the drug. Don't personalize this: He/she's your doctor, not yout mother. Read more It depends if you are splitting the pills and now taking too low of a dose- that could cause a recurrence of depressive symptoms. But in general, it should be ok to split sertraline. The pills have a "score" which means it intends for the patient to cut or split it. Read more In my practice, i start most adults on zoloft (sertraline) at 50 mgs daily, and they do well. Read more See 1 more doctor answer I understand your concern. I then have them increase the dose to 100 - 200 mgs gradually, so they can be at a therapeutic dose. I wait another two to four weeks so that treatment "catches up" to onside effects. Zoloft (sertraline) is a medication for depression and anxiety. Ask yourself for reasons to take 2 medications for anxiety; and for increase of dose of Zoloft (sertraline) to 150mg/day which is a high dose. The recommended starting Zoloft dose for people with depression or obsessive-compulsive disorder (OCD) is Zoloft 50 mg once a day. Your healthcare provider may choose to increase the dosage if symptoms continue, or decrease it if side effects occur. The recommended starting dose of Zoloft for people with panic disorder, post-traumatic stress disorder (PTSD), or social anxiety disorder is Zoloft 25 mg once a day. After a week, your healthcare provider will likely increase the dose to 50 mg of Zoloft once a day. He or she may also choose to increase the Zoloft dosage if symptoms continue, or decrease the dose if side effects occur. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click In order for us to create your customized Health Savvy programs, we need a little more information about the health topic(s) that you are interested in. Zoloft lowest dose Anyone Try Only 12.5 Mg Of Zoloft And Did It Help? - Zoloft., U. S. 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Medscape - Depression, OCD, panic disorder, PTSD, PMDD-specific dosing for Zoloft sertraline, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information.