Published in 1821, to be the first explicit exploration of the creative process and drugs. Whether it’s booze (writers), heroin (rock stars), or cocaine (anyone with money), we’ve long associated, and romanticized the link between, intoxicants and artists’ careers, songs, novels, and films. From Xanax to Adderall to Percocet to the codeine-cough-syrup concoction “lean,” there’s a medicine cabinet’s worth of drugs that are influencing, inspiring, beguiling, and, in some cases, destroying artists. What we haven’t done is reckon with an ascendant crop of pharmaceuticals — some legal, some semi-legal, some illegal — that are now routinely referenced in works of art. We may have a good sense of the artistic reputation of, say, booze — from its effects (getting drunk) to its notable laureates (Cheever), but what is the artistic connotation of lean? Backstory: A combination of amphetamine and dextroamphetamine, Adderall is a rebranded version of Obetrol, which had its FDA approval as a weight-loss drug withdrawn back in 1973. It’s worth asking, given that 33 percent of the rap songs that reached the top ten of May induce: Mental endurance, enhanced concentration, increased focus. Although Adderall is marketed as a treatment for children’s ADHD, by the mid-aughts, adults had become the fastest-growing group using the drug. Cultural connotations: While Adderall, which spikes dopamine levels, can induce euphoria, it’s primarily prized for its reputed capacity to increase mental focus. As such, it’s typically associated not with recreation but persistence and ambition. The writer Tao Lin has confessed to “taking Adderall and staying up all day and night” while writing. Backstory: This product of fermented grains dates back to at least 7,000 B. 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Dre, Snoop Dogg, and more recently Wiz Khalifa cultivated and created a musical sub-genre known as “Weed Rap.” While it’s no secret that many rappers have a deep-seeded love of marijuana, the drug has transcended hip-hop culture and become widely accepted by the mainstream. What once began as a predominantly “hip-hop” lifestyle has gone on to achieve ubiquity. In recent years, another drug-fueled movement has taken shape. “Lean,” which consists of promethazine, codeine, and Sprite, has become the drug o’ choice for more rappers than you might think. Artists like Mac Miller and Sc Hoolboy Q have both battled lean addiction, and Future has made some of his most critically acclaimed music while exploring the dark alleys of lean abuse. 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