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Sertraline indication

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    Sertraline indication


    Sertraline is used for a number of conditions, including major depressive disorder (MDD), obsessive–compulsive disorder (OCD), body dysmorphic disorder (BDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder (SAD). The comparative efficacy of sertraline and TCAs for melancholic depression has not been studied. A 1998 review suggested that, due to its pharmacology, sertraline may be more efficacious than other SSRIs and equal to TCAs for the treatment of melancholic depression. A meta-analysis of 12 new-generation antidepressants showed that sertraline and escitalopram are the best in terms of efficacy and acceptability in the acute-phase treatment of adults with unipolar MDD. Sertraline used for the treatment of depression in elderly (older than 60) patients was superior to placebo and comparable to another SSRI fluoxetine, and TCAs amitriptyline, nortriptyline (Pamelor) and imipramine. Sertraline had much lower rates of adverse effects than these TCAs, with the exception of nausea, which occurred more frequently with sertraline. In addition, sertraline appeared to be more effective than fluoxetine or nortriptyline in the older-than-70 subgroup. placebo in elderly patients showed a statistically significant (that is, unlikely to occur by chance), but clinically very modest improvement in depression and no improvement in quality of life. A meta-analysis on SSRIs and SNRIs that look at partial response (defined as at least a 50% reduction in depression score from baseline) found that sertraline, paroxetine and duloxetine were better than placebo. prednisone for Antidepressant medications are used to treat a variety of conditions, including depression and other mental/mood disorders. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. However, a small number of people (especially people younger than 25) who take antidepressants for any condition may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. Therefore, it is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new antidepressant is started or when the dose is changed. Show More Sertraline is used to treat depression, panic attacks, obsessive compulsive disorder, post-traumatic stress disorder, social anxiety disorder (social phobia), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder). This medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily living.

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    Sertraline as HCl 25mg, 50mg, 100mg; scored tabs. Company Pfizer Inc. Select therapeutic use. Indications for ZOLOFT Panic disorder PD. Posttraumatic. prednisolone and pregnancy Feb 1, 2003. The newest indication for sertraline is the treatment of PMDD. Sertraline has been shown to improve quality-of-life scores and psychologic and. Learn about Zoloft Sertraline Hcl may treat, uses, dosage, side effects, drug. 5% and twice placebo by indication that were not mentioned previously.

    Initial: 50 mg q Day PO given continuously throughout menstrual cycle or given during luteal phase only May increase by 50 mg at the onset of each new menstrual cycle; no more than 150 mg q Day when administered continuously or 100 mg q Day when administered during luteal phase only 25 mg PO q Day initially; may increase by 25 mg every 2-3 days; not to exceed 200 mg q Day Alzheimer dementia related depression: Start at 12.5 mg/day and titrate every 1-2 weeks to response; not to exceed 150-200 mg Renal impairment: Dose adjustment not necessary Mild hepatic impairment (Child-Pugh 5-6): Decrease recommended starting dose and therapeutic dose by 50% Moderate-to-severe hepatic impairment (Child-Pugh 7-15): Not recommended; sertraline is extensively metabolized, and the effects in patients with moderate and severe hepatic impairment have not been studied Clinical worsening and suicide ideation may occur despite medication Use caution in patients with seizure disorders May worsen mania symptoms or precipitate mania in patients with bipolar disorder Increases risk of hyponatremia and impairment of cognitive/motor functions in the elderly Increases risk of bleeding in patients taking anticoagulants/antiplatelets concomitantly Risk of mydriasis; may trigger angle closure attack in patients with angle closure glaucoma with anatomically narrow angles without a patent iridectomy Pregnancy: Conflicting evidence regarding use of SSRIs during pregnancy and increased risk of persistent pulmonary hypertension of the newborn (see Pregnancy) In neonates exposed to SNRIs/SSRIs late in third trimester: Risk of complications such as feeding difficulties, irritability, and respiratory problems Avoid abrupt withdrawal Bone fractures reported with antidepressant therapy; consider the possibility if patient presents with bone pain, bruising, or point of tenderness Coadministration with other drugs that enhance the effects of serotonergic neurotransmission (eg, tryptophan, fenfluramine, fentanyl, 5-HT agonists, St. John’s Wort) should be undertaken with caution and avoided whenever possible due to the potential for pharmacodynamic interaction (see Contraindications) May cause false-positive urine immunoassay screening tests for benzodiazepines SSRIs and SNRIs are associated with development of SIADH; hyponatremia reported Several SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) are metabolized by CYP2D6 CYP2D6 is involved in the metabolism of approximately 20% of drugs in clinical use and displays large individual-to-individual variability in activity due to genetic polymorphisms More than 80 CYP2D6 variant alleles have been identified; however, 4 of the most prevalent alleles, CYP2D6*3, *4, *5, and *6, account for 93-97% of CYP2D6 poor metabolizers CYP2D6*4, the most common variant (~25% frequency in whites), causes a splicing defect; CYP2D6*3 (2.7% frequency) causes a frameshift mutation; and CYP3D6*5 (2.6%) is an entire deletion of the CYP2D6 gene; individuals homozygous for these alleles have no CYP2D6 activity The impact of CYP2D6 activity is further complicated in some SSRIs (eg, fluoxetine, fluvoxamine, paroxetine, sertraline) because in addition to being substrates for CYP2D6, they are also known to moderately inhibit CYP2D6 activity The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. Contact Pfizer Safety to report an adverse event, side effect or concern about the quality of a Pfizer product: (800) 438-1985 You may also contact the U. Food and Drug Administration (FDA) directly to report adverse events or product quality concerns at 1-800-FDA-1088 or gov/Med Watch If you are looking for information about Pfizer studies currently recruiting new patients in your area, you can begin your search on our website. For questions about a Pfizer Clinical Trial, call (800) 718-1021 or email Pfizer Rx Pathways® connects eligible patients, regardless of their insurance status, to a range of assistance programs that offer insurance support, co-pay help, and medicines for free or at a savings. For more information, please call (844) 989-7284 or visit Eligible patients can register for valuable savings offers for nearly 40 brand name medications.

    Sertraline indication

    HIGHLIGHTS OF PRESCRIBING INFORMATION - Pfizer, Antidepressants Update on New Agents and Indications - American.

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    Sertraline/Sertraline Hydrochloride/Zoloft Oral Tab 25mg, 50mg, 100mg. major depression, but the data were not sufficient to support an indication for use. how to buy aciclovir Medical uses. The main indication for SSRIs is major depressive disorder also called "major depression", "clinical depression" and often simply "depression". SSRIs are frequently prescribed for anxiety disorders, such as social anxiety disorder, panic disorders, obsessive–compulsive disorder OCD, eating disorders, chronic pain and occasionally, for posttraumatic stress disorder PTSD. Esomeprazole magnesium is supplied as delayed-release capsules for oral administration. The recommended dosages are outlined in the Table 1. Esomeprazole magnesium delayed-release capsules should be taken at least one hour before duration of proton pump inhibitor administration should be based on available safety and efficacy data specific to the defined indication and dosing.

     
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    or emergency clinicians, the fluoroquinolone antibiotics have been a staple in combating both outpatient and inpatient infections. The first fluoroquinolone (ciprofloxacin/Cipro) came on the market in 1987, and since then there have been a raft of new quinolones added to the drug class. The fluoroquinolones have been shown to have a wide spectrum of biologic activity and are effective against a large number of bacteria pathogens. But post-marketing surveillance has demonstrated a growing number of serious and unexpected side effects. Perhaps the most commonly known unique side effect of the quinolones relate to their effect on connective tissue – particularly in the Achilles tendons. The relationship between tendon pathology and the quinolones was noted back in 1983, but the FDA was very reluctant to “Black Box” the drugs until a lawsuit filed by the non-profit “Public Citizen” pressured the FDA to acknowledge the problem. In the end the boxed warning took 25 years to appear, finally surfacing in 2008. The first lawsuit regarding tendon rupture occurred in 2010 when a Minnesota jury awarded .8 million to 82-year-old John Schedin who had bilateral achilles ruptures after being given levofloxacin for a respiratory infection along with some steroids by his family doctor. The Risks of Antibiotics Fluoroquinolones and Tendonitis Time where can i buy viagra in pakistan Magnesium Helps Heal Cipro Damage - Fluoroquinolone Antibiotics Linked to Serious Nerve Damage
     
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