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    The Patient Information Leaflet (PIL) is the leaflet included in the pack with a medicine. It is written for patients and gives information about taking or using a medicine. It is possible that the leaflet in your medicine pack may differ from this version because it may have been updated since your medicine was packaged. Below is a text only representation of the Patient Information Leaflet. The original can be viewed in PDF format using the link above. The text only version may be available from RNIB in large print, Braille or audio CD. For further information call RNIB Medicine Leaflet Line on 08. antabuse and diabetes Therapy may be instituted before the results of the cultures and other laboratory studies are known; however, once these results become available, anti-infective therapy should be adjusted accordingly. Fluconazole is not recommended for use in children and adolescents under the age of 16 years, unless antifungal treatment is imperative, and no suitable alternative agent exists, due to insufficient safety and efficacy (see section 5.2). Coadministration of terfenadine is contraindicated in patients receiving Fluconazole 150mg capsule at multiple doses of 400 mg per day or higher based upon results of a multiple dose interaction study. Coadministration of other medicinal products known to prolong the QT interval and which are metabolised via the cytochrome P450 (CYP) 3A4 such as cisapride, astemizole, pimozide, quinidine and erythromycin are contraindicated in patients receiving fluconazole (see sections 4.4 and 4.5). Fluconazole 150 mg capsule has been associated with rare cases of serious hepatic toxicity including fatalities, primarily in patients with serious underlying medical conditions. In cases of fluconazole-associated hepatotoxicity, no obvious relationship to total daily dose, duration of therapy, sex or age of patient has been observed. Fluconazole hepatotoxicity has usually been reversible on discontinuation of therapy.

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    Fluconazole is a type of medicine called a triazole antifungal. It kills fungi and yeasts by interfering with their cell membranes. Fluconazole works by stopping fungi and yeasts from producing a substance called ergosterol, which is an essential component of their cell membranes. Fluconazole causes holes to appear in the cell membranes, which allows essential constituents of the fungal or yeast cells to leak out. This kills the fungi or yeast, which either clears up the infection or prevents it from developing. Fluconazole is used to treat and prevent a number of different types of fungal and yeast infections, particularly those caused by Candida or Cryptococcus species of fungi. Fluconazole can be taken by mouth (as capsules or suspension) or may be administered via a drip into a vein (intravenous infusion) depending on the type and severity of the infection. The length of treatment needed depends on the type and severity of the infection. Fluconazole 150mg capsules are also available without a brand name, ie as the generic medicine. Vaginal thrush is the common term for infections of the vagina with Candida species of fungi, in particular Candida albicans. This infection causes inflammation and discharge from the vagina. In men it causes soreness and redness of the penis, tightness of the foreskin, or a white, odourless discharge from the penis. Fluconazole kills the Candida fungi causing the thrush infection by making holes appear in their cell membranes. This allows essential constituents of the fungal cells to out, which kills the fungi and clears up the infection. Medicines and their possible side effects can affect individual people in different ways.

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