Nordazepam (INN; marketed under brand names Nordaz, Stilny, Madar, Vegesan, and Calmday; also known as nordiazepam, desoxydemoxepam, and desmethyldiazepam) is a 1,4-benzodiazepine derivative. Like other benzodiazepine derivatives, it has amnesic, anticonvulsant, anxiolytic, muscle relaxant, and sedative properties. However, it is used primarily in the treatment of anxiety disorders. It is an active metabolite of diazepam, chlordiazepoxide, clorazepate, prazepam, pinazepam, and medazepam. Nordazepam is among the longest lasting (longest half-life) benzodiazepines, and its occurrence as a metabolite is responsible for most cumulative side-effects of its myriad of pro-drugs when they are used repeatedly at moderate-high doses; the nordazepam metabolite oxazepam is also active (and is a more potent, full BZD-site agonist), which contributes to nordazepam cumulative side-effects but occur too minutely to contribute to the cumulative side-effects of nordazepam pro-drugs (except when they are abused chronically in extremely supra-therapeutic doses). Common side effects of nordazepam include somnolence, which is more common in elderly patients and/or people on high-dose regimens. Hypotonia, which is much less common, is also associated with high doses and/or old age. buy doxycycline mexico Anyone who knows much about winemaking knows that the romantic stereotype of life in the vines is just that – a stereotype. Winemaking can be romantic, of course; but it can also be risky and fraught with uncertainty. After all, Mother Nature has a long history of being a fickle master. Consider Pierre Bernault, owner of an ancient chateau and plot of vines in Montagne Saint Emilion where he and Stéphane Derenoncourt craft Montesquieu Winery’s Moulin du Paradis blend: “You can lose an entire year’s income by surprise in the course of three weeks because of weather,” says Pierre. “But I like to take risks.” Good thing, because in 2008, Pierre lost 66% of the year’s wine production in three minutes. A vicious hailstorm descended upon his estate without warning, destroying the majority of his fruit. Like a trained missile, the hail hit only Pierre’s property, leaving his neighbors’ adjacent vines untouched. 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