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Although the study was funded by Pfizer, the lead author was Steven Nissen, MD, a cardiologist at the Cleveland Clinic, who was one of the first physicians to sounds alarms about links between Vioxx and an increased risk of heart attack and stroke. Published in the New England Journal of Medicine, the study not only found that all 3 medications had similar efficacy, but all had nearly the same rate of heart disease, heart attack or stroke from taking it. CELEBREX is an FDA-approved NSAID (nonsteroidal anti-inflammatory drug) used to treat the signs and symptoms of osteoarthritis (OA) and rheumatoid arthritis (RA), juvenile rheumatoid arthritis in patients 2 years and older, and ankylosing spondylitis; and for the management of acute pain in adults, and for the management of menstrual cramps. Some patients and their doctors prefer brand-name medications. 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