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    The TGA is reviewing new information regarding domperidone (Motilium) and its potential effects on the patient's heart, particularly with doses above 30 mg daily. Domperidone is a medicine used for relief of symptoms of nausea and vomiting, and delayed stomach emptying. The European Medicine Agency's Pharmacovigilance Risk Assessment Committee (PRAC) has recently recommended restricting the dose of domperidone to less than 30 mg daily and duration of use to one week due to the risk of heart problems, including . The process for considering whether to implement these changes across the European Union is ongoing. The PRAC recommendation is scheduled to be formally assessed on 22-24 April 2014. In addition to reviewing the PRAC recommendation, the TGA will be assessing new information provided by the sponsor, Janssen-Cilag, to evaluate the benefit-risk profile of domperidone and determine if new measures are required to ensure its safe use in Australia. In particular, the TGA will consider whether any changes should be made to the maximum dose and duration of use for Australian patients. where to buy metformin in canada Consumer Medicine Information This leaflet answers some common questions about MOTILIUM tablets. It does not take the place of talking to your doctor or pharmacist. Your doctor has weighed the risks of you taking MOTILIUM against the benefits this medicine is expected to have for you. MOTILIUM is used to treat the following conditions in adults: MOTILIUM is an antiemetic and a prokinetic medicine. If you have any concerns about taking MOTILIUM ask your doctor or pharmacist. It works by blocking the action of a chemical messenger in the brain which causes the feeling of nausea and vomiting, as well as increasing the movement or contractions of the stomach and intestines, allowing food to move more easily through the stomach. Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed MOTILIUM for another reason. Do not take MOTILIUM if: MOTILIUM should not be used in children. If you have not told your doctor or pharmacist about any of the above, tell them before you start taking or are given MOTILIUM. Your doctor will advise you whether or not to take MOTILIUM or if you need to adjust the dose or alter your treatment.

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    Now that you’re committed to organizing your closets and dressers, getting started can be difficult because you may not know where to begin. Relax for a second and then follow the below steps to a create a clutter less wardrobe. Designate an area to put everything from your closet and dressers; we recommend using your bed to avoid having to bend or crouch on the floor. Once everything is removed from your closet and dresser drawers, it’s time to begin sorting. Clothes in your laundry basket is an automatic keep; they have obviously been worn recently and are part of your weekly rotation. A good rule of thumb is, if you haven’t worn an item in over a year, it’s time to part with it. Before you toss something, inspect it for holes, fraying seams, missing buttons, etc. Joanna is a freelance medical writer with a BSc (Hons) in Medical Science & Pharmacology and 15 years' experience working in the field of medical communications. Journalistic work includes clinical research summaries, interviews, feature articles and reportage from major medical congresses. Work for pharmaceutical industry encompasses medical education, marketing material, copywriting and direct-to-consumer materials. Domperidone (Motilium), used to treat nausea and vomiting, will be a prescription-only medicine (POM) from 4 September 2014, the Medicines and Healthcare products Regulatory Agency (MHRA) has announced. The move is part of a class 2 medicines recall triggered by concerns about the potential cardiotoxicity of the drug, which is a dopamine antagonist with antiemetic properties. A recent European Medicines Agency (EMA) review found that domperidone was associated with a small increased risk of serious cardiac side effects. It warned that domperidone should no longer be used for the treatment of bloating and heartburn and that the drug was contraindicated in people with underlying heart conditions and other risk factors. It also said the drug’s use in children was under review.

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