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    There is a community of self-experimenters who are taking the drug Metformin, not because they are diabetic or prediabetic, the FDA-approved reasons for prescribing the drug, but rather because they believe it probably has an impact in promoting general health and retarding aging(ref). In fact, it is probably the pharmaceutical most used for this purpose. The purpose of this blog entry is to discuss Metformin as it has been shown to reduce all cause mortality in various studies, and discuss its understood mechanisms of operation. This blog entry is Part 2 of interventions that reduce all cause mortality. Metformin is a traditional and inexpensive drug that is the first line of treatment for people with Type 2 Diabetes or prediabetic conditions. The first blog entry in this series, which was also Part 4 of the inflammation series. It is a drug that has been extensively studied, both with respect to the impacts of using it and as to the molecular mechanisms of its operations. Image source Metformin “originates from the French lilac or ”“Metformin has been used for over 40 years as an effective glucose-lowering agent in type 2 DM. Typically it reduces both basal and post-prandial hyperglycaemia by about 25-30% on over 90% of type 2 DM patients when given either alone or in combination with other therapies —”(ref)Clinical trials of Metformin Clinical lists 1989 clinical trials mentioning Metformin but only three clinical trials mentioning Metformin and longevity. One is called the Metformin in Longevity Study (MILES)sponsored by the Albert Einstein College of Medicine is currently listed as active but not recruiting and is the only study where aging is the unique endpoint condition. Cardiovascular and metabolic effects of metformin in patients with. duloxetine delayed release Building the clinical evidence on metformin and cancer - Cancerworld Repurposing metformin for cancer treatment current clinical studies
     
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