The objective of this study was to prepare and evaluate some physiochemical and biopharmaceutical properties of bitter taste masking microparticles containing azithromycin loaded in dispersible tablets. In the first stage of the study, the bitter taste masking microparticles were prepared by solvent evaporation and spray drying method. When compared to the bitter threshold (32.43 µg/ml) of azithromycin (AZI), the microparticles using AZI: Eudragit L100 = 1:4 and having a size distribution of 45–212 µm did significantly mask the bitter taste of AZI. Fourier transform infrared spectroscopy (FTIR), and proton nuclear magnetic resonance spectroscopy (H NMR) proved that the taste masking of microparticles resulted from the intermolecular interaction of the amine group in AZI and the carbonyl group in Eudragit L100. Differential scanning calorimeter (DSC) analysis was used to display the amorphous state of AZI in microparticles. Images obtaining from optical microscopy and scanning electron microscopy (SEM) indicated the existence of microparticles in regular cube shape with many layers. In the second stage, dispersible tablets containing microparticles (DTs-MP) were prepared by direct compression technique. amoxicillin with food [Indication] This product is indicated for infections caused by susceptible bacteria as follows: Infection of the upper respiratory tract like the otitis media, nasosinusitis, pharyngitis and chronic tonsillitis; Infection of the lower respiratory tract like the bronchitis and pneumonia; Herpes genital infection caused by chlamydia trachomatis and the one caused by non-MDR neisseria gonorrhoeae (exclusive of the concurrent infection caused by treponema pallidum).[Usage and Dosage] The treatment course and usage for curing infectious diseases with azithromycin dispersible tablets is as follows: Adult: For sexually transmitted diseases caused by chlamydia trachomatis or susceptible neisseria gonorrhoeae, take it orally 1.0 (4 tablets) at per time. 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