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    Adults: 1cm ribbon of ointment should be placed inside the lower conjunctival sac five times a day at approximately four hourly intervals, omitting the night time application. Treatment should continue for at least 3 days after healing is complete. A post-marketing aciclovir pregnancy registry has documented pregnancy outcomes in women exposed to any formulation of Zovirax. The registry findings have not shown an increase in the number of birth defects described amongst Zovirax exposed subjects compared with the general population, and any birth defects showed no uniqueness or consistent pattern to suggest a common cause. Systemic administration of aciclovir in internationally accepted standard tests did not produce embryotoxic or teratogenic effects in rabbits, rats or mice. In a non-standard test in rats, foetal abnormalities were observed but only following such high subcutaneous doses that maternal toxicity was produced. The clinical relevance of these findings is uncertain. During Hokusai's lifetime Japan was a nation ruled by strict social class, a feudal regime and military dictatorship. The Edo period, as this division of Japanese history came to be known, saw great social and economic change and would eventually lead to the downfall of the ruling elite and the beginning of Japan's Modern Age. Foreign influence was beginning to shape the political future of the nation and as a direct consequence of this Japanese culture would begin to affect the West. The Edo period, named after the city of Edo (now present day Tokyo), lasted for over two hundred and fifty years. The rulers of Japan during this time were the Tokugawa Shoguns. Through an unbroken line of fifteen Shoguns, the Tokugawa clan governed Japan and shaped it's destiny. Listed here are just some of the Tokugawa Shoguns and a brief summary of their time as Japan's ruler.

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