Chloroquine in hepatic amoebiasis

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  1. Skazi User

    Chloroquine in hepatic amoebiasis


    The 5-nitroimidazoles are more effective in the latter context, but when they are not available it is justifiable to use chloroquine instead. Chloroquine is more frequently used as an adjunct to dehydroemetine in the treatment of hepatic abscess.

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    After a full discussion on the diagnosis and treatment of amoebiasis, the author describes a clinical trial in cases of hepatic amoebiasis. Twenty consecutive patients were treated with chloroquine they comprised persons of European origin as well as Armenians, Anglo-Indians, Chinese and Indians. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. It is taken by mouth. Common side effects include muscle problems, loss of appetite, diarrhea, and skin rash. Serious Rarely, when patients of amoebic liver abscess are vomiting, injection chloroquine can be used in a dose of 0.3–0.6 G. base in 24 hours not exceeding 0.9 G. Chloroquine given alone is a safer drug than emetine in amoebic liver abscess, but unfortunately the relapse rate is almost 25%.

    Absorption from the gastrointestinal tract is efficient and peak plasma concentrations occur within 2-3 hours. It is claimed to increase the prospect of cure during the first course of treatment.

    Chloroquine in hepatic amoebiasis

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  7. J Trop Med Hyg. 1951 Oct;5410198-206. The treatment of hepatic amoebiasis with chloroquine. LANE R. PMID 14881212 PubMed - indexed for MEDLINE

    • The treatment of hepatic amoebiasis with chloroquine..
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    ARALEN, chloroquine phosphate, USP, is a 4-aminoquinoline compound for oral administration. It is a white, odorless, bitter tasting, crystalline substance, freely soluble in water. ARALEN is an antimalarial and amebicidal drug. Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Chloroquine diphosphate is a medicine indicated for the treatment of malaria caused by Plasmodium vivax, Plasmodium malariae and Plasmodium ovale, hepatic amebiasis, rheumatoid arthritis, lupus and diseases that cause sensitivity of the eyes to light.

     
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