Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Intermittent preventive therapy chloroquine Plaquenil for apd Plaquenil dosing by weight Lupus on plaquenil Sulphasalasine was helpful in my case but took 12 weeks to kick in. After a while it wasn't as effective and I too was prescribed methotrexate alongside. The side effects of the methotrexate for me were horrendous chronic chest infections and I'm now asthmatic as a result. I refuse to take it now even if its my passport to biologic treatment. Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. If the plaquenil is helping and they say you need it, I'd take it - the side effects will go away. I've not had experience with sulfasalazine - but from what I've read, the side effects of that med are about the same as those of plaquenil. BTW - sulfasalazine is an anti-inflammatory. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Taking hydroxychloroquine and sulfasalazine together side effects Hydroxychloroquine Side-effects, uses, time to work, Hydroxychloroquine Oral Route Precautions - Mayo Clinic All well and plaquenilChloroquine cocktail with valium and zopicloneWhat is the mechanism of action of chloroquine Jan 01, 2006 Radiographic improvement was seen in the combination therapy as well. Median Larsen scores were 4 for the combination therapy group and 12 for the sulfasalazine with or without prednisolone group P = 0.005 12. At 5 years, the damage was still significantly lower with the combination therapy P = 0.001. Combination Therapy for Rheumatoid Arthritis in the Era of.. Plaquenil and sulfasalazine - Autoimmune Disorders - MedHelp. What are the side effects of using hydroxychloroquine.. Hydroxychloroquine received an overall rating of 7 out of 10 stars from 368 reviews. See what others have said about Hydroxychloroquine, including the effectiveness, ease of use and side effects. If you are taking hydroxychloroquine for symptoms of rheumatoid arthritis, your symptoms should improve within 6 months. If your rheumatoid arthritis symptoms do not improve, or if they worsen, stop taking the drug and call your doctor. Once you and your doctor are sure the drug works for you. Taking plaquenil and sulfasalazine Arthritis Information. loss of appetite- Just wondering what kind of side effects any of you are experiencing- esp if you are taking plaquenil and/or prednisone along with it. I really hope after I'm through w the prednisone that my puffy face will go away Hello!