It is bioactivated hepatically to its primary metabolite, N-desethylamodiaquine, by the cytochrome p450 enzyme CYP2C8. Among amodiaquine users, several rare but serious side effects have been reported and linked to variants in the CYP2C8 alleles. Spell hydroxychloroquin Plaquenil for behcet's Purpose of plaquenil in lupus Structure, properties, spectra, suppliers and links for Chloroquine Phosphate, 1446-17-9. Amodiaquine is a 4-aminoquinoline compound related to chloroquine. Amodiaquine was first made in 1948. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. The wholesale cost is about US$0.01 per dose as of 2014. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. People who are poor metabolizers of amodiaquine display lower treatment efficacy against malaria, as well as increased toxicity. CYP2C8*1 is characterized as the wild-type allele, which shows an acceptable safety profile, while CYP2C8*2, *3 and *4 all show a range of "poor metabolizer" phenotypes. Iupac name of chloroquine Chloroquine phosphate C18H32ClN3O8P2 - PubChem, Amodiaquine - Wikipedia Chloroquine cytotoxic falicparum Chloroquine - chemical information, properties, structures, articles, patents and more chemical data. Chloroquine, CAS Number 58175-87-4. Hydroxychloroquine - Wikipedia. Chloroquine - Wikipedia. Chloroquine diphosphate salt is used to study the role of endosomal acidification in cellular processes, such as the signaling of intracellular TLRs. It can be used as DNA intercalator & to dissociate antigen antibody complexes without denaturing red blood cell antigens. Name Chloroquine sulfate Drug Entry Chloroquine. Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. 4 It was the drug of choice to treat malaria until the development of newer antimalarials such as pyrimethamine, artemisinin, and mefloquine. 17 Chloroquine was granted FDA Approval on 31 October 1949. 19 The PDB entry listed in the links table is for R-chloroquine. Marketed formulations may contain chloroquine phosphate PubChem CID 64927. The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.