I didn't seem to have any problems whatsoever with it initially, other than very short term and mild cramping/diarrhea. But now I've been dealing with considerable muscle aching and pain/spasm in some new places - or at least places that haven't bothered me in quite awhile. Hydroxychloroquine combination arimidex Heme chloroquine complex Plaquenil neck pain Chloroquine proguanil malaria prophylaxis My main issue is joint pain. I was put on Plaquenil, and it seemed to help a little, but I still noticed things bothering me. I went off of it thinking it wasn't helping. The past 2 weeks, my joint pain has been the worst it's ever been. I limp when I walk, I can't sleep, and I find doing certain tasks wear me out fast. Lupus arthritis causes pain, stiffness, swelling, tenderness and warmth in your joints. The joints most often affected are the ones farthest from the middle of the body, such as fingers, wrists, elbows, knees, ankles and toes. Hate it. before my diagnosis I was tired,aneamic,stiff etc since the plaquenil I jus flare all the time. it was so bad I just came off it for several months. got so ill they wanted me to go on chemo based drugs but I did not want that either. so reluctantly went back on the plaquenil. imo its made me worse. I felt the Plaquenil helped the fatigue, but it seems the pain is sabotaging that effect. My knees and legs hurt, back, hips, shoulders, fingers, and now my left heel - which has me limping half the time. Can plaquenil cause joint pain Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, How Lupus Affects the Muscles, Tendons and Joints Lupus. Is plaquenil used to treat lupusHydroxychloroquine lung diseaseHydroxychloroquine drug Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Hydroxychloroquine Plaquenil Side Effects & Dosage for.. When starting hydroxychloroquine do symptoms feel. - LUPUS UK. The Risk of Retinal Toxicity with Plaquenil. Knee pain was the most common complaint, followed by shoulder and hip pain, but joint pain can affect any part of your body, from your ankles and feet to your shoulders and hands. As you get older. Plaquenil has helped my muscle/joint pain immensely. Have you considered that Lupus may be throwing some inflammation your way - ie joint/muscle pain, a Lupus flare - rather than blaming a medication that in general decreases those symptoms? Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis.