Chloroquine autophagy mechanism

Discussion in 'Plaquenil' started by Lineria, 14-Mar-2020.

  1. globoxchange Guest

    Chloroquine autophagy mechanism


    Pharmacological modulators of this pathway have been extensively utilized in a wide range of basic research and pre-clinical studies. Bafilomycin A1 and chloroquine are commonly used compounds that inhibit autophagy by targeting the lysosomes but through distinct mechanisms.

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    The mechanism through which chloroquine is acting on cancer cells has mainly been attributed to the inhibition of autophagy as a consequence of its lysosomotropic properties 13, 24. Consistently, we also observed a strong inhibitory effect of chloroquine on autophagy in the established PDAC cell lines previously used in the cited studies. Dec 13, 2019 Inhibition of autophagy using chloroquine or hydroxychloroquine has already shown promise in clinical trials and numerous other clinical trials are ongoing to determine the optimal tumors to treat. Since 5-FU induced autophagy in GBC cells, and CQ inhibited autophagy, our findings suggest a possible mechanism that CQ inhibited 5-FU-induced autophagy, which modified the cytotoxicity of 5-FU. The combination therapy of CQ and 5-FU should be considered as an effective strategy for the treatment of gallbladder carcinoma.

    To address this, we cultured primary rat cortical neurons from E18 embryos and used the Seahorse XF96 analyzer and a targeted metabolomics approach to measure the effects of bafilomycin A1 and chloroquine on bioenergetics and metabolism. Since it is now clear that mitochondrial quality control, particularly in neurons, is dependent on autophagy, it is important to determine whether these compounds modify cellular bioenergetics.

    Chloroquine autophagy mechanism

    Chloroquine C18H26ClN3 - PubChem, Autophagy in cancer moving from understanding mechanism to.

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  5. Nov 15, 2015 Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4.

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    Pharmacological modulators of this pathway have been extensively utilized in a wide range of basic research and pre-clinical studies. Bafilomycin A1 and chloroquine are commonly used compounds that inhibit autophagy by targeting the lysosomes but through distinct mechanisms. Among them, only CQ and its derivate hydroxychloroquine HCQ are FDA-approved drugs and are thus currently the principal compounds used in clinical trials aimed to treat tumors through autophagy inhibition. However, the precise mechanism of how CQ blocks autophagy remains to be firmly demonstrated. As Stanislovas mentioned, chloroquine is another autophagy inhibitor, however the mechanism by which it inhibits autophagy is completely different and it mainly block late autophagy. Chloroquine.

     
  6. girl4look Well-Known Member

    Hi - I just started Plaquenil (400 mg a day) two week ago and I started feeling less achy and tired a few days ago. Health Issues - Drug Interactions / Side Effects Plaquenil. The Risk of Retinal Toxicity with Plaquenil Stopping Plaquenil - General Discussion - Life With Lupus
     
  7. web-master82 Guest

    Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. HYDROXYCHLOROQUINE - ORAL Plaquenil side effects, medical. Common Plaquenil side effects a study from FDA data. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  8. ebonoserv Guest

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