Both medications are commonly used to treat patients with systemic autoimmune diseases that include the following: The pathogenic effect of plaquenil is the induction of lysosomal dysfunction in photoreceptors and retinal pigment epithelium (RPE) cells. A lysosome is a membrane-bound organelle found in the cytoplasm of most cells and it contains hydrolytic enzymes that function in intracellular digestive processes. Eye exam for plaquenil use Using chloroquine to treat glioblastoma The ellipsoid zone EZ, which has had a contentious naming history and has previously been called the connecting cilia, inner segment-outer segment junction, photoreceptor integrity line, and inner ellipsoid zone, is significantly reflective and separates the myoid zone and the photoreceptor outer segments.3. The integrity of the EZ often. Photoreceptor Integrity Line. The purpose of this text is to depict and analyze the photoreceptor integrity line PIL or the IS/OS junction of the inner and outer segments in the normal and abnormal eyes with macula and retinal diseases. This book includes 67 cases that fall into the following categories; congenital, acquired, retinal vascular. The photoreceptor integrity line is important, because it’s a biomarker of photoreceptor integrity, both rods and cones. And the term PIL for the receptor integrity line does not limit the usefulness of the concept of a biomarker, regardless of the precise anatomical location, which is subject to debate and change. So the right photoreceptor. In the normal retina, the retinal pigment epithelium digests the tips of the photorectors by lysosomal action. When hydrolytic enzymes are released into the cytoplasm, they cause self-digestion of the cell. Photoreceptor integrity line plaquenil Pigment dropout found in middle-aged man’s first eye exam, Photoreceptor Integrity Line Worldeyecare Indication of chloroquine Purpose To evaluate the integrity of the photoreceptor inner segment and outer segment IS/OS junction using spectral-domain optical coherence tomography SD OCT in patients with diabetic macular edema and to correlate the relationship between the integrity of the IS/OS junction and visual acuity. Design Observational, prospective study. The relationship between photoreceptor IS/OS junction changes and.. Lecture Interpretation of OCT Retina from A-Z Cybersight. Photoreceptor Integrity Line as Revealed by Spectral Domain OCT by.. Bull’s Eye Retinopathy Early macular toxicity can cause stippling or mottling of the RPE Next, granular pigmentation and loss of the normal foveal reflex can occur It’s believed but not proven that if early macular changes are detected and the medication is stopped, any toxicity that has occurred can be reversed.1 If the maculopathy continues to progress, concentric zones of. Photoreceptor damage is characterized by defects in the photoreceptor integrity line that are detectable with spectral-domain OCT; Early clinical signs include perifoveal ganglion cell damage that is characterized by localized thinning of the outer nuclear layer Start studying Plaquenil Problems. Learn vocabulary, terms, and more with flashcards, games, and other study tools.