Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Does plaquenil effect healing after bone surgery What does generic plaquenil look like Hydroxychloroquine diabetes Plaquenil and chronic fatigue Name /bks_53161_deglins_md_disk/hydroxychloroquine 03/07/2014 AM Plate # 0-Composite pg 1 # 1 PDF Page #1 Canadian drug name. Genetic Implication. Hydroxychloroquine-related hyperpigmentation on the face A and areas of previous bruising on the arm B of a 48-year-old man with systemic lupus erythematosus. HYDROQUINONE USP, 4% SKIN BLEACHING CREAM is indicated for the gradual bleaching of hyperpigmented skin conditions such as chloasma, melasma, freckles, senile lentigines, and other unwanted areas of melanin hyperpigmentation. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Hydroxychloroquine hyperpigmentation Hydroxychloroquine-Associated Hyperpigmentation Mimicking Elder Abuse, Hydroxychloroquine-related skin discoloration CMAJ What does chloroquine do Hydroxychloroquine-associated hyperpigmentation with gray to black discoloration. Mucocutaneous hyperpigmentation because of anti-malarial therapy has been reported since World War II 2 ; however, HCQ-associated hyperpigmentation seems to be less common than with other antimalarials such as chloroquine 3, 4. Hydroxychloroquine-induced Hyperpigmentation of the Skin.. Hydroquinone Cream - FDA prescribing information, side.. Annular Atrophic Lichen Planus Responds to Hydroxychloroquine.. Oct 30, 2008 Rare, previous reports of hyperpigmentation indicate the presence of both melanin and hemosiderin in patients being treated with antimalarial medication. To our knowledge, this staining pattern for hydroxychloroquine has not been previously reported in the literature and supports that hydroxychloroquine, in addition to chloroquine, binds to melanin. Hydroxychloroquine sulfate is a colorless crystalline solid, soluble in water to at least 20 percent; chemically the drug is 2-4-7-Chloro-4-quinolylaminopentylethylamino ethanol sulfate 11. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. An elderly woman presented with 6 months history of skin coloured to erythematous papules in annular pattern over extremities, upper back and neck. The patient was diagnosed with granuloma annulare GA and started on hydroxychloroquine HCQ 300 mg daily. After 4 months of treatment, she developed bluish grey pigmentation within the plaques of GA with normal surrounding skin figure 1A,B.