While many of these can be grouped by anatomic location or type of toxicity, there are also individual medications with characteristic effects. In this article, we will describe several major categories of pharmacologic retinal toxicity and discuss examples of individual medications. Plaquenil hydroxychloroquine retinopathy Hydroxychloroquine sulphate bp 200mg Rituxan interac with plaquenil Nov 01, 2007 The syndrome is characterized by headache, nausea, vomiting, tremor, hypotension, and loss of consciousness and is associated with profound vision loss, which may be irreversible. 27 There is mild retinal edema and venous dilation in the acute phase. Over several weeks, arteriolar attenuation and optic atrophy develop. Symptoms of Plaquenil toxicity are similar to other macular problems and may include Decreased fine vision or difficulty reading. Changes in Color vision Missing Spots or shadows near the center of the vision Patients who present with Plaquenil toxicity typically exhibit depigmentation that is located circumferentially around the macula, giving it a “bull’s eye” pattern. Consequently, this clinical finding is often termed bull’s eye maculopathy. Both medications have been shown to bind melanin and to concentrate in the iris, ciliary body and retinal pigment epithelium, altering normal physiologic function. Chloroquine (Aralen) and hydroxychloroquine (Plaquenil) are traditional antimalarial agents now used in the treatment of autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Plaquenil macular edema Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects., Plaquenil Toxicity Screening - Retina Group of New York Effects of plaquenil on the eyesChloroquine schizontsPlaquenil dosage for arthritis Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Plaquenil Side Effects Common, Severe, Long Term -. Pause the Plaquenil?. Macular Edema Symptoms - American Academy of Ophthalmology. The aim of this study is to report a rare case of macular edema as a presentation of hydroxychloroquine-related retinal toxicity. We presented a case of a 46-year-old female patient using hydroxychloroquine for underlying rheumatoid arthritis RA with blurred vision over the left eye. Nov 01, 2015 H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The early signs of hydroxychloroquine toxicity are macular edema and/or bilateral granular depigmentation of the RPE in the macula. With continued exposure to the drug, this can progress to an atrophic bullseye maculopathy with concentric rings of hypopigmentation and hyperpigmentation surrounding the fovea. As mentioned above, these findings may be in the peripheral macula near the arcades in patients of Asian descent.