I know minocycline is an antibiotic related to doxycycline, yet I looked plaquenil up and found that it is a DMARD, used to treat malaria, rheumatoid arthritis and lupus. Plaquenil can change the intracellular PH and make antibiotics more effective. It works especially well with macrolide antibiotics. I wasn’t reacting well on the combination (too hard on my digestive system, severe herxing - but I have to add that I don't know which abx caused the problems), but most of my dr’s patients react very well. I found no connection to treating Lyme except that when used in combination with minocycline is affective at treating Lyme arthritis, and is fools insurance companies into thinking arthritis is exactly what is being treated. It's very common for LLMD's to use Plaquenil in all kinds of protocols. It can cause eye problems (I didn’t have them, but I had to stop this combination after 6 weeks). Chloroquine phosphate over the counter Natural alternatives to hydroxychloroquine Many doctors prescribe a cocktail of doxycycline and azithromycin for late-stage Lyme disease. The antibiotics are often prescribed so that the patient takes doxycycline twice daily for months straight, while pulsing shorter courses of azithromycin once per month. DIAGNOSIS AND TREATMENT OF LYME DISEASE A Culmination of the Literature – Kent Holtorf, MD Characteristics of Borrelia burgdorferi 1. Over 1500 gene sequences 2. At least 132 functioning genes. Eligible patients had persistent symptoms related to a prior Lyme disease diagnosis, confirmed either by the presence of a rash, a tick bite in a Lyme-endemic area, or a positive IgM or IgG test. Patients received two weeks of open-label intravenous ceftriaxone, and were then randomized to one of three treatment arms 12 weeks oral doxycycline, 12 weeks oral clarithromycin-hydroxychloroquine, or 12 weeks of placebo. We should always watch for side effects that can be damaging!! Yet, of the millions of symptoms Lyme has caused me, arthritis isn't one. My pharmacist (and the dr also afterwards) advised me to get my eyes checked before starting treatment, so that my dr would know for sure where the damage comes from, if I had any showing up. Lyme combination azithromycin doxycycline hydroxychloroquine Lyme Disease Treatment & Management Approach., Dr. Holtorf on Lyme Disease Diagnosis and Treatment - A. Hydroxychloroquine sleHydroxychloroquine hyperkalemiaDoes plaquenil make your skin darkIs hydroxychloroquine the same as plaquenil If Zithromax azithromycin is used orally to treat Lyme disease, it is ineffective unless it is used with a "cyst-buster" such as Flagyl metronidazole or Plaquenil hydroxychloroquine. Check out Dr. Burrascano's treatment guidelines, starting on Page 14, regarding the different antibiotics used to treat Lyme disease. Zithromax Z-Pak - can it be used for lymes disease treatment?. Are Longer-term Antibiotics More Effective than Shorter.. Drug Combinations against Borrelia burgdorferi Persisters.. In this 3-arm study, entitled Persistent Lyme Empiric Antibiotic Study Europe PLEASE, ceftriaxone followed by doxycycline arm 1 or ceftriaxone followed by the combination of clarithromycin and hydroxychloroquine arm 2 are compared to short-term therapy with ceftriaxone followed by placebo arm 3. Here, we describe the study protocol. Lyme disease is the most commonly reported vector-borne disease in the United States. Although most patients respond well to antibiotic treatment, 10-20% suffer chronic symptoms of carditis, arthritis, and neurological impairment months after treatment. The cause of these symptoms is still undetermined, but there are many theories Doxycycline is an antibiotic used in the treatment of infections caused by bacteria and certain parasites. It is used to treat bacterial pneumonia, acne, chlamydia infections, early Lyme disease, cholera, typhus, and syphilis. It is also used to prevent malaria and in combination with quinine, to treat malaria.