Hydroxychloroquine and reduction of metastasis

Discussion in 'International Pharmacy' started by FLYPROMOTE, 27-Feb-2020.

  1. MumCakactuats Moderator

    Hydroxychloroquine and reduction of metastasis


    It's used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus, rheumatoid arthritis, and others. Malaria is spread by mosquitoes, which transmit the parasites that cause the infection, usually in tropical and subtropical parts of the world.

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    Lysosome-associated agents have been implicated as possible chemo-sensitizers and immune regulators for cancer chemotherapy. We investigated the potential roles and mechanisms of hydroxychloroquine HCQ in combination with chemotherapy in lung cancer treatment. The effects of combined treatment on non-small cell lung cancer NSCLC were investigated using cell viability assays and animal. The risk of metastasis was not significantly different between the two groups. However, it was significantly lower during the exposure period when compared with the unexposed adjusted sHR 0.64 0.44-0.95 for the overall population and 0.61 0.38-1.00 for those diagnosed with incident cancers. Several studies have shown that hydroxychloroquine positively affects insulin and glucose metabolism.4,7,8,10,11,12,13 In fact, the highlighted point of the present study was the effects of hydroxychloroquine on glucose control in the prediabetes, state independent of its effect on body weight and composition as well as on the lipid profile.

    For example, it may be combined with an antibiotic to treat chronic Q-fever, which humans usually catch from farm animals or raw milk. Plaquenil is used to treat other types of infections too.

    Hydroxychloroquine and reduction of metastasis

    Hydroxychloroquine Information for Providers AIDSinfo, Effects of chronic exposure of hydroxychloroquine.

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  6. Hydroxychloroquine HCQ enhances the anti-cancer activity of the histone deacetylase inhibitor, vorinostat VOR, in pre-clinical models and early phase clinical studies of metastatic colorectal cancer mCRC. Mechanisms could include autophagy inhibition, accumulation of ubiquitinated proteins, and subsequent tumor cell apoptosis.

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    Hydroxychloroquine and chloroquine may reduce the risk of cancer as they inhibit autophagy, in particular, in people with connective tissue hazard ratios of cancers, metastases, and death were assessed in adults with connective tissue diseases. Hydroxychloroquine and chloroquine are antimalarial drugs commonly used for the treatment of rheumatic diseases. Multiple mechanisms might explain the efficacy and adverse effects of these drugs. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine

     
  7. marik550 User

    Does anyone know how likely it is for hydroxychloroquine to cause hair loss? Weight loss is also listed as a side effect, I am up 15 Linda 8 mo into this drug👀😤😃😁Everyone is different. I’m not ill enough to of interest to him generally! I couldn't 100 % say it is due to the mets though but my hair has gone thinner since I started taking the meds. However, Hydroxychloroquine slows down and mitigates lupus symptomatology so it will slow up hair loss. The only real side effect is on vision in those susceptible to that; annual testing for a couple of years is advisable and if that is OK you can forget visual deterioration more or less. Being on iron and B vitamins no matter what the blood tests say about levels has pretty much settled my hair down. Hair loss with hydroxychloroquine? Does anyone. - LUPUS UK Hair loss and Plaquenil? DailyStrength Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus
     
  8. Ksenio Well-Known Member

    Ask the Expert Archive • Page 169 of 189 • Johns Hopkins. I am reading about TNF blockers such as Humira, Enbrel, Remicade and others. I have crohns and was just wondering what the difference is in the different types of TNF blockers and why they work for some illnesses and not others. What is the difference in Enbrel or Humira vs, Remicade that it will not work for crohns?

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  9. rulfer Moderator

    SARCOIDOSIS TREATMENT GUIDELINES SARCOIDOSIS TREATMENT GUIDELINES INTRODUCTION Sarcoidosis is a chronic inflammatory granulomatous dis-ease that primarily affects the lungs, although multi-organ involvement is common. The etiology of sarcoidosis is not clear; however, genetic and environmental factors probably play a role in the development and expression of the disease.

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