Swiss albino mice were administered with different amounts of CQ ranging from human therapeutic equivalent of 360 mg/kg body wt. We observed statistically significant generation of reactive oxygen species, liver toxicity, and oxidative stress. Our observation of alterations in biochemical parameters was strongly supported by real-time PCR measurement of m RNA expression of key biochemical enzymes involved in hepatic toxicity and oxidative stress. Pompe glycogen storage and hydroxychloroquine Chloroquine cyanosis Hydroxychloroquin eye In the case of 100 mg kg −1 day −1 the effect was highly signiﬁcant compared with the other doses 10 and 30 mg kg −1 day −1. The results of the study revealed that α‐lipoic acid could offer protection against chloroquine‐induced hepatotoxicity. α‐Lipoic acid had a better protective effect when compared with silymarin, a. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. Activity in vitro and in vivo. Chloroquine is active against the erythrocytic forms of Plasmodium vivax. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. We further tested quercetin, an antioxidant flavanoid, against CQ-induced hepatoxicity and found encouraging results as quercetin was able to drastically reduce the oxidative stress and hepatotoxicity resulting at higher dosages of CQ administration. However, the observed hepatotoxicity and accompanying oxidative stress following CQ administration show dose specific pattern with little or apparently no effect at therapeutic dose while having severe effects at higher dosages. Effect of chloroquine on liver enzymes Chloroquine - Uses, Dosage, Side Effects, Composition., Aralen Chloroquine Uses, Dosage, Side Effects. Medicine plaquenil 200 mg Plaquenil has never raised my liver enzymes and I have been on it for six years. The only time my ALT and AST were elevated when I was taking too much iron supplements for my anemia. Once I stopped those, the enzymes went back to normal. Plaquenil and elevated liver enzymes?. Chloroquine Oral Uses, Side Effects, Interactions.. Chloroquine - FDA prescribing information, side effects and uses. Mar 25, 2002 The phenomenology of mefloquine's adverse effect profile, together with incidental details in some of the published case reports references to alcohol, and to known hepatotoxic co-medications such as the oral contraceptive pill suggest that for many mefloquine users adverse drug effects may be the result of primary hepatocellular injury, caused by the drug in association with one or more concurrent liver insults. Our Plaquenil hydroxychloroquine Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication. It is also occasionally used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus.