Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil pronounciation Chloroquine and pregnancy Hydroxychloroquine mechanism of action in lupus HYDROXYCHLOROQUINE is used to treat rheumatoid arthritis and systemic lupus erythematosus. It is also used to treat malaria. The lowest GoodRx price for the most common version of generic Plaquenil is around $18.60, 90% off the average retail price of $196.17. Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Hydroxychloroquine Plaquenil is the most commonly prescribed because it is generally believed to cause fewer side effects; chloroquine Aralen has a reputation for more serious side effects, but it may be prescribed in situations where hydroxychloroquine cannot be used. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Lupus and plaquenil side effects Plaquenil Side Effects on Your Eyes and Vision, Hydroxychloroquine Plaquenil I don't like plaquenilChloroquine related chloroformMethotrexate plaquenil combination Re Plaquenil side effects. Plaquenil made me a bit nauseated in the beginning but that wnet away within a few weeks. You usually need to be on Plaquenil for a few mon ths for it to take effect. I have read several times that those going from brand name Plaquenil to generic have had problems, including flares. Plaquenil side effects - HealthBoards. Treating Lupus with Anti-Malarial Drugs Johns Hopkins.. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. With all of the physical and emotional complications that lupus can cause, it’s easy to overlook symptoms that seem minor at first. But take this advice Don’t ignore changes in vision. While side effects of corticosteroids are usually to blame, there is also the possibility of ocular damage. Side effects associated with Plaquenil are placed in three categories common, less common, and rare. If you have any of the following effects and they persist or worsen, notify your doctor or pharmacist promptly. It is important to remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more.