It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine other uses Plaquenil toxicity 10-2 Hydroxychloroquine sulfate side effects rheumatoid arthritis Plaquenil shortage 2017 Your eye care provider can examine the macula and detect subtle changes before you begin to notice any symptoms of problems. As a result, all patients taking plaquenil should have an examination approximately every six months. The macula should be examined through a dilated pupil. The incidence of Plaquenil related macular problems increases when approaching a dose of 600 to 700 mg. per day. When allowed to advance, hydroxychloroquine retinal toxicity leads to loss of up to three visual functions acuity, peripheral vision and night vision. Signs. On examination, a telltale sign of hydroxychloroquine toxicity is a bilateral change in the retinal pigment epithelium of the macula that gives the commonly described appearance of a bull’s-eye. Toxicity from hydroxychloroquine may be seen in two distinct areas of the eye the cornea and the macula. The cornea may become affected relatively commonly by an innocuous cornea verticillata or vortex keratopathy and is characterized by whorl-like corneal epithelial deposits. Today, it is used to treat rheumatoid arthritis, some symptoms of lupus, childhood arthritis (or juvenile idiopathic arthritis) and other autoimmune diseases. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Hydroxychloroquine eye problems Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Hydroxychloroquine-Induced Retinal Toxicity - American. Chloroquine pretreatment degradation toxicityHydroxychloroquine retinopathy pathogenesis Hydroxychloroquine over a long time more than five years can also cause damage to your retina, the light-sensitive coating at the back of your eye. For this reason, you will be asked to attend eye screening tests. It is important to tell your doctor if you have any. eye problems at any time while you are taking hydroxychloroquine. Eye tests Hydroxychloroquine – what you can expect when starting treatment. Hydroxychloroquine - Wikipedia. Plaquenil hydroxychloroquine Basics, Side Effects & Reviews.. Plaquenil Hydroxychloroquine is used to treat and prevent malaria infection, and to reduce symptoms and progression of autoimmune diseases such as lupus & others. I took plaquenil in 2005 and loved it. Best drug ever! Then suddenly I started to have eye pain in 2007 for no reason and even ear pain. I stopped it and it went away. My eye doc had no explanation and i had never had any signs of toxicity in my eyes. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble.