It works by preventing or treating malaria, a red blood cell infection transmitted by the bite of a mosquito. However, this medicine is not used to treat severe or complicated malaria. Chloroquine phosphate for quarantine marine fish Aralen 250 mg Aug 05, 2015 About a month ago, I finally decided to start taking the Plaquenil. I took 100 mg daily for a week since I'm highly sensitive to new medications, with the goal of reaching 400 mg daily after three weeks. One of my most bothersome symptoms is muscle weakness and fatigue, and the Plaquenil seemed to exacerbate it dramatically. Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Rarely, hydroxychloroquine can lead to anemia in Diagnosis of Drug-induced Myopathies. A drug-induced, or toxic, myopathy is defined as the acute or subacute manifestation of myopathic symptoms such as muscle weakness, myalgia, creatine kinase CK elevation, or myoglobinuria that can occur in patients without muscle disease when they are exposed to certain drugs. It is also used to treat acute and chronic rheumatoid arthritis. Hydroxychloroquine is used to treat discoid lupus erythematosus (DLE) or systemic lupus erythematosus (SLE or lupus). Plaquenil muscle weakness Muscle Weakness? -, PATIENT FACT SHEET Hydroxychloroquine Plaquenil Lupus alternatives to plaquenilPlaquenil side effects weight gainPlaquenil maculopathy monitoringHydroxychloroquine and t cells Plaquenil antibiotics are part of the fluoroquinolone antibiotics. Muscle weakness is a side effect. I would be very cautious! Quinolone antibiotics are chemotherapeutic and late side effects months to years later are common. Plaquenil weakness - Road Back Foundation. Drug-related Myopathies of Which the Clinician Should Be Aware. Plaquenil Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs. General feeling of tiredness or weakness headache inability to move the eyes increased blinking or spasms of the eyelid joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs loss of hearing lower back or side pain noisy breathing painful or difficult urination Aug 20, 2013 I thought that maybe the Plaquenil caused my weakness as it increased vastly right after I started it, but I think it was the flexeril I was taking for the twitching and jerking as I stopped that and the weakness became better. My PCP told me that it's rare to have weakness with plaquenil but more common with flexeril. Apr 28, 2009 This is a new question concerning an old post. Plaquenil and muscle pain. I thought that maybe my question had been answered when I read that Plaquenil was responsible for your muscle pain but, as I read on I realize it was not. I TOO have severe muscle pain and cramping in my legs. Only when trying to sleep.