Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Chloroquine plus proguanil Adverse effect of hydroxychloroquine Currently, one of the primary functional screening tests recommended for the evaluation of Plaquenil retinal toxicity is 10-2 white stimulus automated visual fields; however, research shows Asian patients benefited from 24-2 or 30-2 visual fields, given that toxicity often manifests changes beyond the macula in these patients. 9 Because spectral-domain optical coherence tomography SD-OCT is readily accessible and able to detect early structural damage prior to clinical funduscopic findings. Remember, any patient who is at a high risk for Plaquenil toxicity should be examined on an annual basis following the baseline exam. The goal of monitoring/screening is to identify early macular damage prior to irreversible vision loss or even before visible signs of bull’s eye maculopathy. Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy Retinal toxicity from chloroquine CQ and its analogue, hydroxychloroquine HCQ, has been recognized for many years. Chloroquine toxicity remains a problem in many parts of the world, but is seen less frequently in the United States where the drug largely has been replaced by HCQ. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Testing for plaquenil usage Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects., New Plaquenil Guidelines Plaquenil vs cbd oilWhat is the difference between hydroxychloroquine and hydroxychloroquine sulfateChloroquine bioavailabilitySide effects of taking hydroxychloroquineAutofluorescence test for plaquenil toxicity Ophthalmologists should use Humphrey visual field test and OCT — and fundus autofluorescence if available can help, too — to detect signs of HCQ toxicity, Moshfeghi said. “The bottom line is. Despite Plaquenil dosing recommendations, retinal toxicity.. Recommendations on Screening for Chloroquine and.. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Hydroxychloroquine Screening Recommendations. Baseline Screening. Fundus examination within the first year of use; Add visual fields and SD OCT if maculopathy is present; Annual Screening. Begin after 5 years of use; Sooner in the presence of major risk factors *SD OCT Spectral Domain Optical Coherence Tomography Plaquenil Toxicity Screening Plaquenil Toxicity Screening Plaquenil Toxicity Screening Hydroxychloroquine Sulphate Plaquenil medication has been effectively used for many years for a variety of infectious and autoimmune conditions, including rheumatoid Arthritis RA and Systemic Lupus Erythematosus SLE. On rare occasion, and usually after many years, Plaquenil can damage the central. Usage Hydroxychloroquine is usually taken with food or milk to prevent stomach upset. The dosage and length of treatment are based on your medical condition and response to therapy. In children.