Method of action of chloroquine

Discussion in 'Generic Chloroquine' started by 0-0, 21-Feb-2020.

  1. Victor XenForo Moderator

    Method of action of chloroquine


    Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells.

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    Chloroquine is used to prevent or treat malaria caused by mosquito bites in countries where malaria is common. Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This paper presents the current state of knowledge on chloroquine disposition, with special emphasis on stereoselectivity and microsomal metabolism. In addition, the impact of the patient’s physiopathological status and ethnic origin on chloroquine pharmacokinetics is discussed. In humans, chloroquine concentrations decline multiexponentially. Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA.

    Both drugs may be needed for a complete cure and to prevent the return of infection (relapse). In some cases, you may need to take a different medication (such as primaquine) to kill the malaria parasites living in other body tissues.

    Method of action of chloroquine

    Chloroquine - FDA prescribing information, side effects., Clinical Pharmacokinetics and Metabolism of Chloroquine.

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  6. Few drugs are available to prevent or treat infections with such parasites and relatively little is known about the modes of action of even such widely used compounds as chloroquine or primaquine. However, much has been learned from investigations of the methods by which the parasites develop resistance to various antimalarials.

    • Mechanisms of Action of Antimalarial Drugs SpringerLink.
    • Chloroquine - FDA prescribing information, side effects and uses.
    • On the molecular mechanism of chloroquine's antimalarial..

    Chloroquine is an aminoquinoline that is quinoline which is substituted at position 4 by a 5-diethylaminopentan-2-ylamino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis. From a pharmaceutical perspective, I think I would have considered N, SN or Chloroquine. N is hard to get with lots of challenges and opportunities for your efforts not to work. SN is a second option for me due to easy availability but chloroquine appeals to me in it's method of action. Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug. On the.

     
  7. igordejak Moderator

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Hydroxychloroquine Dosage Guide with Precautions - Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION
     
  8. Mikelandjelo Guest

    Chronic Pancreatitis Cedars-Sinai Acute pancreatitis is a sudden inflammation of your pancreas. If your acute pancreatitis doesn’t get better and slowly gets worse, you have chronic pancreatitis. If you have chronic pancreatitis, the digestive enzymes that would normally travel by tubes inside your pancreas and empty into your upper intestine, become trapped inside your pancreas.

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