After two years of treatment, leflunomide is as safe as sulfasalazine and more effective. Leflunomide's efficacy and adverse events are similar to those of methotrexate. Methotrexate plaquenil alcohol Statistics about chloroquine Methotrexate and plaquenil treatment Plaquenil baseline testing If a patient is resistant to initial DMARD treatment with an agent such as methotrexate, combination DMARD treatment may be used, adding one or more conventional DMARDs leflunomide, hydroxychloroquine, sulfasalazine or a newer biologic treatment to methotrexate. I was diagnosed with RA and was put on sulfa, my rheumy tried adding mtx but i had awful side effects so am now on hydroxychloroquine and sulfa.this combination worked for anyone? just wondered how other people got on with it. Apr 09, 2008 This guide summarizes evidence comparing the effectiveness and safety of disease-modifying antirheumatic drugs DMARDs and corticosteroids used for rheumatoid arthritis RA. It does not address other drugs that are no longer commonly used as first-line treatment for RA, such as azathioprine, chloroquine, cyclosporine, gold, and penicillamine. It also does not discuss analgesics, such as. [Evidence level A, systematic review of randomized controlled trials]. Leflunomide costs significantly more than sulfasalazine and methotrexate. Combination of sulfasalazine hydroxychloroquine and leflunomide for ra Hydroxychloroquine Plaquenil - medications for Rheumatoid Arthritis RA, Combination hydroxychloroquine and sulfasalazine - do. - HealthUnlocked Hydroxychloroquine toxicity octChloroquine davis The Finnish Rheumatoid Arthritis Combination Therapy trial also provides data on the benefit of combination therapy in patients with early, clinically active RA 2 years. In an open-label trial, patients were randomized to triple therapy or sulfasalazine, with or without prednisolone, for 2 years. Combination Therapy for Rheumatoid Arthritis in the Era of.. Choosing Medications for Rheumatoid Arthritis - NCBI Bookshelf. What are the side effects of using hydroxychloroquine.. Original Article from The New England Journal of Medicine — Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications Leflunomide, sulfasalazine, and hydroxychloroquine are effective therapies in RA and are commonly employed in combination therapy. Although the precise mechanisms of action of the traditional DMARDs are incompletely understood, most have both anti-inflammatory and immunomodulatory actions. With so many drug options, doctors will work with you to determine the best combination of therapy to treat your RA. In 2012, researchers led by Larry W. Moreland, M. D. studied oral triple.