Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Ra hydroxychloroquine Did plaquenil work for you If experienced, these tend to have a Severe expression. Abnormal Liver Function Tests. Acute Liver Failure. Acute Pustular Eruptions On Skin. Bronchospasm. Decreased Blood Platelets. Decreased White Blood Cells. Deficiency Of Granulocytes A Type Of White Blood Cell. Quinacrine Atabrine Quinacrine is another alternative, but it is prescribed less often because it can sometimes cause a yellow discoloration of the skin. It is sometimes given in addition to hydroxychloroquine if the Plaquenil on its own is not adequately managing symptoms. Plaquenil Side Effects. Generic Name hydroxychloroquine. Note This document contains side effect information about hydroxychloroquine. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Can plaquenil discolor yiur skin Discolored skin from prednison and plaquenil - Dermatology., Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Is there a generic drug for plaquenilCan i just stop taking hydroxychloroquineHydroxychloroquine perscriptinsPlaquenil canadaWhy is plaquenil prescribed for lupus I have have been on plaquenil for over a year. It's really made my RA manageable, however, Plaquenil is an anti-malarial and pretty well known for its possible skin discoloration side effects. As you can guess from the title, I now have a beautiful melasma mustache and melasma across my cheeks and forehead. It's great. Melasma skin discoloration from medication rheumatoid. Plaquenil Side Effects Common, Severe, Long Term -. Skin Discoloration and Plaquenil - Arthritis Information. The plaquenil made me lose my hair immediately. When it came back in most of it came in white which I read that the medicine can bleach your hair. Then last year I noticed areas on my legs that are brown or maybe it's that my skin has been bleached in areas and is very white. Contact your healthcare professional immediately in case of any of the following You have symptoms of eye problems. These include blurred or worsening vision, ringing in the ears, hearing loss, unusual bleeding or bruising, blue or black skin discoloration, muscle weakness, bleaching or loss of hair, mood or mental changes. You become pregnant. I have been on Plaquenil for two years for RA, for which it has been great apart from a bit of itchiness, which I've mentioned elsewhere on this site in reply to another member asking about this. But lately the skin on my arms looks a bit blotchy. By this I mean that there are numerous small whiter-coloured circles whiter than the surrounding skin, anyway, almost like scars, or rather like.