I'm not completely pain free, but it's a lot better than it was. I've been on plaquenil since mid June I have had a lot of stress in my life so I can't determine what is causing what. Not seeing any improvements with pain but I just went to 0 prednisone 3 weeks ago. said give it a few months and if I don't see any improvement I might as well go off of it. Wanted to let you know that I was on plaquenil for about three years and I told my RA doctor that my fatigue was worse. It just seems like the fatigue is worse than it has ever been, and it doesn't seem to matter if I go to bed early or take a nap during the day. Woke up and cleaned the kitchen an hour later(my kitchen is a galley kitchen 8 ft maybe.no time) Took a nap. Early on I did get those stomach cramps and diarrhea. All my pain is tolerable and he sees no deformities so he says he doesn't see RA activity. Just because the pain is tolerable doesn't make me like it any better. He did a plaquenil test and sure enough it was low. Can hydroxychloroquine be used for mrsa Plaquenil used for psoriasis Chloroquine cathepsin Hydroxychloroquine arthritis forum Hydroxychloroquine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies, or to become more depressed. If you or your caregiver notice any of these side effects, tell your doctor right away. This medicine may cause hypoglycemia low blood sugar. Plaquenil hydroxychloroquine is an antimalarial medication used to treat or prevent malaria, a disease caused by parasites, which enter the body through the bite of a mosquito. Plaquenil is also used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. It does make you nauseous for a while after you take it, and some people swear it made them a bit dizzy, so it could take some getting used to. If you can stand it, try to stay on it, as the long term effects are worth it for me and many others. I wake up tired in the morning, get my kids fed and off to the schoolbus, and some days that's all I can do until it's time to go pick them up and make dinner, then I collapse after the kids are put to bed. I don't know if this is just the way RA is, or if it is a side effect of the medicine. Wasn't going to eat luch because I would have to move to do it.husband bought out. Kids came home, helped with homewrok, made dinner..picked up couch(because my blanket and pillow were there) Went to bed at 9. Does hydroxychloroquine make you sleepy Does Plaquenil make you tired? DailyStrength, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil and sunburnChloroquine stability in waterPlaquenil cause blindnessPlaquenil and hidradenitis suppurativaSynthesis procedure of chloroquine Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. It does not work against certain types of malaria chloroquine-resistant. The United States Center for. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Plaquenil Do you feel sick when it kicks in?. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. I suspect that holds true for you too. Maybe someone else will tell you differently, but I haven't known anyone else that found Plaquenil to make them tired. Pace and rest when you can and if you can exercise a little try to do that. My daughter couldn't exercise at all until recently. Now she can just a little. How to use Plaquenil. Lupus and/or rheumatoid arthritis patients will most likely take this medication by mouth, usually once or twice daily or as directed. Hydroxychloroquine generally is given to adults in doses of 200 mg or 400 mg per day. In some cases, higher doses can be used.