Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Taking hydroxychloroquine for ra Methotrexate and hydroxychloroquine side effects Plaquenil mechanism of action Chloroquine is a prescription It's interesting that methotrexate is sometimes used to treat multiple sclerosis, but folks who use methotrexate MUST supplement with extra Folic Acid at least 1mg daily to avoid the toxic effects. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Took Plaquenil for years-no results. Changed neuros and even the Ms neuro thought I had Sjogren's due to history - positive Schrimer test, swollen and infected parotid glands, joint pain, etc. Finally Ms neuro ordered a lip biopsy which confirmed once and for all that I did NOT have SS but I had MS. I only have 2 classic MS lesions on MRI. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil to treat ms Plaquenil and Lichen Sclerosus - Reviews, Hydroxychloroquine Plaquenil Is there another drug like plaquenilRheumatoid arthritis choosing initial treatment plaquenil vs enbrelPlaquenil sulfate 200 mg oral tablet People with MS aren’t the only ones at risk for PML. Other disease conditions that elevate one’s risk include HIV/AIDS, rheumatoid arthritis, Crohn’s disease, lupus, leukemia, Hodgkin’s disease, lymphoma, or other cancers. Organ transplant recipients are also at risk. The MS Alphabet Plaquenil, PML, PPMS, and Other 'P' words.. Sjogren's and MS - Multiple Sclerosis - MedHelp. MS symptoms. Or is it from the Plaquenil, Elavil? Arg! - Lupus. I took Plaquenil for suspected Sjogren's syndrome for over 3 years. It did absolutely nothing for symptoms that evenutally would be diagnosed as MS. This is just my personal experience and you didn't say which connective tissue disease you had so this may not apply to you. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. No known abuse potential. As an opioid antagonist, naltrexone is used as a treatment for substance abuse. LDN does not exert any euphoric or reinforcing effects, and we have observed no cases of LDN misuse or abuse. Furthermore, we have not seen the development of dependence and tolerance with the medication.