Hydroxychloroquine metabolism

Discussion in 'Generic & Brand Canadian Pharmacy' started by Ch_, 15-Mar-2020.

  1. VIPSITEIN Moderator

    Hydroxychloroquine metabolism


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Jan 05, 2020 Hydroxychloroquine is a well tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity. Within the eye, hydroxychloroquine negatively impacts the cornea, ciliary body, and retina. Hydroxychloroquine has similar pharmacokinetics to chloroquine, with rapid gastrointestinal absorption and elimination by the kidneys. Cytochrome P450 enzymes CYP2D6, 2C8, 3A4 and 3A5 metabolize hydroxychloroquine to N-desethylhydroxychloroquine. Pharmacodynamics. Antimalarials are lipophilic weak bases and easily pass plasma membranes. Plaquenil ® hydroxychloroquine sulfate is a white or practically white, crystalline powder, freely soluble in water; practically insoluble in alcohol, chloroform, and in ether. The chemical name for hydroxychloroquine sulfate is 2-4-7-Chloro-4-quinolylaminopentylethylamino ethanol sulfate 11. Its structural formula is

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Hydroxychloroquine metabolism

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Hydroxychloroquine - Wikipedia

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  5. Metabolism. Partially metabolized; major metabolites are desethylhydroxychloroquine and desethylchloroquine. 100 Bisdesethylchloroquine, a carboxylic acid derivative, also formed in small amounts. 100. Elimination Route. Hydroxychloroquine and its metabolites slowly excreted by the kidneys. 100. Stability Storage Oral Tablets

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    The amount of hydroxychloroquine excreted in the urine as unchanged drug ranges from 6% to 60% median 23%, and 17% is excreted in the urine as metabolized drug. Twenty-four percent to 25% of hydroxychloroquine is excreted in feces, 5% is sloughed off in skin, and 45% is stored in lean tissues. Hydroxychloroquine HCQ is a 4-aminoquinoline class molecule traditionally used as an antimalarial medication, but currently being investigated in over 50 cancer clinical trials either alone or in combination with chemotherapy ClinicalTrials.gov. Oct 30, 2019 Limitations of use Hydroxychloroquine is not effective against chloroquine- or hydroxychloroquine-resistant malaria strains of Plasmodium species; not recommended for treatment of complicated malaria, malaria prophylaxis in regions with chloroquine resistance, or treatment when the Plasmodium species has not been identified; hydroxychloroquine does not prevent relapses of P. vivax and P. ovale infections because it is not effective against the hypnozoite forms of these parasites.

     
  6. Bryn User

    Download PDF Despite the advent of newer drugs, hydroxychloroquine (HCQ) continues to be a mainstay in the treatment of systemic lupus erythematosis (SLE), rheumatoid arthritis (RA), and other connective tissue diseases. Hydroxychloroquine Serum Concentrations and Flares of. Cardiac Complications Attributed to Chloroquine and. New Screening Guidelines for Hydroxychloroquine Toxicity
     
  7. CobaltD New Member

    Alopecia areata treated with hydroxychloroquine A. Mar 25, 2018 Alopecia areata is a common hair loss condition that is often emotionally devastating for patients. There is a paucity of effective treatments available. Hydroxychloroquine has been reported as variably effective in inducing significant hair regrowth in adults with alopecia areata.

    Consider hydroxychloroquine in treating pediatric alopecia areata.