It does not work against certain types of malaria (chloroquine-resistant). The United States Center for Disease Control provides updated guidelines and travel recommendations for the prevention and treatment of malaria in different parts of the world. Ocular testing for plaquenil Chloroquine half life mouse Hydroxychloroquine pustular rash Macular degeneration plaquenil I was diagnosed with RA in march and have been on increasing dose of methotrexate. Yesterday my rheumatologist started me on hydroxychloroquine as well. Is anyone else on this combination and have you had any problems with it as I know hydroxychloroquine can cause eye sight problems. Thanks In defense of your ophthalmologist, the eye problems with Plaqueni, although rare are dose related. Comparison of Plaquenil and methotrexate is difficult. Both drugs are very well tolerated and have different side effects, but if you have other medical problems, one drug might be better for you and you should discuss this with your rheumatologist. Find information about common, infrequent and rare side effects of Methotrexate Anti-Rheumatic Oral. This medication is also used, usually with other medications, to treat certain auto-immune diseases (lupus, rheumatoid arthritis) when other medications have not worked or cannot be used. Discuss the most recent information with your doctor before traveling to areas where malaria occurs. Side effects of plaquenil and methotrexate Compare Plaquenil vs Methotrexate -, Plaquenil vs Methotrexate Antineoplastics Cancer drugs. Can you take birth control with plaquenilGeneric plaquenil price increase This study is created by eHealthMe based on reports of 23,242 people who take Methotrexate and Plaquenil from Food and Drug Administration FDA, and is updated regularly. On eHealthMe, you can evaluate side effects and drug interactions from 15 million FDA reports. Methotrexate and Plaquenil drug interactions - eHealthMe. Common and Rare Side Effects for Methotrexate Anti-Rheumatic.. Hydroxychloroquine Side Effects, Dosage, Uses, and More. The more common side effects of methotrexate can include nausea or vomiting. stomach pain or upset. diarrhea. hair loss. tiredness. dizziness. chills. headache. sores in your lungs. mouth sores. painful skin sores. bronchitis. fever. bruising more easily. increased risk of infection. Methotrexate vs plaquenil side effects long term and short term I was recently diagnosed with an autoimmune disease that mainly fuses my joints together, but causes severe pain and fatigue. The only problem is the Plaquenil causes severe headaches that interfer with my daily activities also. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember.