Patients with morphea typically develop red patches on the skin, usually on the abdomen, chest, and back. Occasionally, patches may form on the face or the arms and legs. Chloroquine doxycycline Hydroxychloroquine metabolism cyp Aralen uses Plaquenil low dose Morphea skin - morphea scleroderma causes. Morphea types inear morphea & morphea profunda. Morphea skin disease treatment. Conditions. such as oral methotrexate Rheumatrex, Trexall. This may be used in combination with corticosteroid pills for the first few months. Add hydroxychloroquine; Add phototherapy UVA1 or PUVA if available. For severe or widespread morphea, treatment may include the use of ultraviolet light phototherapy. Oral medications. For severe or widespread morphea, your doctor may prescribe an immunosuppressive medication, such as oral methotrexate Trexall, corticosteroid pills or both. Or your doctor may suggest hydroxychloroquine Plaquenil. Disabling pansclerotic morphea involves all layers of the skin. Used in combination, hydroxychloroquine, prednisone, and methotrexate seemed to slow disease progression in case 1. There has been limited success with penicillamine, antimalarials. There have been reports of disease response to UVA-1 phototherapy.3. Some patients may have only one patch of thickened skin, and others may have several patches. These discolored patches tend to become firm, dry, and smooth over time, and they are often oval in shape. Hydroxychloroquine and phototherapy combination morphea REFERENCES - UpToDate, Morphea - Diagnosis and treatment - Mayo Clinic Ciprofloxacin and hydroxychloroquineHydroxychloroquine headacheDoes hydroxychloroquine interact with potassiumChloroquine dengueIcd 10 screening on plaquenil Regimen. Topical therapies, phototherapy, and sys-. our patient received a combination of bendamustine and ritux-imab. Bothbendamustine,analkylatingagentderived from nitrogen mustard, and rituximab, a chimeric. We describe a patient with a unique combination of morphea, PBC, and WM who responded to maintenance therapy with rituximab. Morphea associated with primary biliary cirrhosis and.. Disabling pansclerotic morphea Clinical presentation in.. Phototherapy and Photochemotherapy PUVA for Skin Conditions.. Review question. The aim of this Cochrane Review was to assess the effects of treatments, either given in isolation or combination, for people with morphea morphoea, when compared with an inactive substance placebo, no intervention, any other treatment, or different doses or duration of a collected and analysed all relevant studies published up to July 2018. Morphea may present at any age. In children, the linear subtype predominates while in adults’ plaque and generalized subtypes are most common. Morphea occurs more frequently in women, especially in adults where female predominance is marked 51. Morphea is not the same as scleroderma systemic sclerosis, and it does not become scleroderma. Anti-malarial drugs, such as Plaquenil hydroxychloroquine, is often used to manage lupus and can also be effective in scleroderma. Plaquenil is thought to interfere with communication between immune cells, which can suppress the damaging effect of an overly active immune response without raising a patient’s risk of susceptibility to infections.