It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Keyhole macula chloroquine Plaquenil build up Plaquenil and sex drive Corneal verticillata, or vortex keratopathy, manifests as a whorl-like pattern of golden brown or gray deposits in the inferior interpalpebal portion of the cornea in a clockwise fashion Fig 12-15. A variety of medications bind with the cellular lipids of the basal epithelial layer of the cornea due to their cationic, amphiphilic properties. Keratopathy described also as whorled or verticillate; thus, the term cornea verticillata or a diffuse corneal haze, punctate keratopathy, or crystalline precipitates. Plaquenil® are. Plaquenil side effects start off by effecting the surface of the eye the cornea leading to verticillata. Verticillata are deposits of salts within the corneal epithelium. This does not cause any symptoms to the patient and is reversible when the medication is stopped. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Cornea verticillata plaquenil Cornea verticillata - Wikipedia, Drug-Induced Corneal Epithelial changes Plaquenil equivalent Cornea • Retina Quick sidebar •Corneal verticillata whorl keratopathy •“ hloroquine, and less frequently HCQ, can cause whorl-like intraepithelial deposits verticillata in the cornea. These corneal changes are not a direct marker for retinal damage, are not associated with visual loss, and in contrast COPE Disclosures Plaquenil Toxicity Update. Plaquenil Related Eye Problems - Fraser Eye. Chloroquine And Hydroxychloroquine Toxicity - StatPearls - NCBI Bookshelf. Feb 16, 2016 Systemic lupus erythematosus SLE is a chronic multisystem autoimmune disease. The eye is frequently involved in SLE.1 The disease may cause ocular involvement by several mechanisms including immune complex deposition in the basement membrane of endothelial cells of the small blood vessels.1 Ocular complications have been reported in up to one-third of patients with SLE.2 Ocular. A number of systemic drugs induce corneal epithelial changes characterized by deposits that might present as a vortex keratopathy described also as whorled or verticillate; thus, the term cornea verticillata or a diffuse corneal haze, punctate keratopathy, or crystalline precipitates. Corneal verticillata. Is Plaquenil maculopathy reversible? Not once it become clinically apparent. Can it progress after discontinuation of the drug? Yes. What is the mechanism of continued vision loss after drug discontinuation? It is believed to be due to the ongoing loss of previously-injured cells. A.