I can say that the prednisone wean was successful, even after having only been on plaquenil a few months. To answer some of your other questions, it was the same timeframe for me. Synthroid and plaquenil Hydroxychloroquine and kidney Quit plaquenil Plaquenil and liver toxicity The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. As PLAQUENIL may enhance the effects of a hypoglycemic treatment, a decrease in doses of insulin or antidiabetic drugs may be required. Drugs That Prolong QT Interval And Other Arrhythmogenic Drugs. PLAQUENIL prolongs the QT interval and should not be administered with other drugs that have the potential to induce cardiac arrhythmias. But I couldn't handle the heart issue and not being able to breathe (plus all the other pains). Yesterday would've been my 4th day at the reduced dose. Plaquenil withdrawal side effects Long-Term Side Effects of Plaquenil for Rheumatoid., Plaquenil Oral Uses, Side Effects, Interactions. Plaquenil and night sweats Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Rarely, hydroxychloroquine can lead to anemia in PATIENT FACT SHEET Hydroxychloroquine Plaquenil. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. HYDROXYCHLOROQUINE - ORAL Plaquenil side effects.. Comment Plaquenil is the devil! Worked well 1st 2 mts. After that I had issues with my vision, felt waves of nervousness, and extreme anxiety where I started to question my sanity. Hallucinated, broke out in rashes and crying spells. Plaquenil Hydroxychloroquine belongs to a group of medications known as anti-inflammatories and antimalarials. It is used alone or in combination with other anti-arthritic medications to treat rheumatoid arthritis. It helps to reduce pain, stiffness, and swelling in joints. If common side effects do occur, they are usually minor and last only for a short period of time. Please note the rare side effects listed below, specifically retinopathy, which causes damage to the eyes. Side effects associated with Plaquenil are placed in three categories common.