The inset shows a cross section of a normal red blood cell with normal haemoglobin. Figure (B) shows abnormal, sickled red blood cells sticking at the branching point in a vein. Hydroxychloroquine dose for malaria Hydroxychloroquine sulfate tabs 200mg and eczema Sickle cell disease is an inherited blood disorder that affects more than 90,000 Americans, mostly of African descent. The condition arises from a genetic defect that alters the structure of hemoglobin, the oxygen-carrying protein found in red blood cells. Sickle cell disease SCD is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle cell anaemia SCA. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. This leads to a rigid, sickle-like shape under certain circumstances. Sickle cell disease SCD is a group of inherited red blood cell disorders. In SCD, the red blood cells become hard and sticky and look like a C-shaped farm tool called a “sickle.” People with SCD can live full lives and enjoy most of the activities that other people do. The terms "sickle cell crisis" or "sickling crisis" may be used to describe several independent acute conditions occurring in patients with SCD, which results in anaemia and crises that could be of many types, including the vaso-occlusive crisis, aplastic crisis, sequestration crisis, haemolytic crisis, and others. The inset image shows a cross-section of a sickle cell with long polymerized sickle haemoglobin (Hb S) strands stretching and distorting the cell shape to look like a crescent. Sickle cell disease plaquenil Sickle Cell Disease Children's Hospital of Philadelphia, Sickle cell disease - Wikipedia Plaquenil toxicity macula powerpointHydroxychloroquine dosage for malaria preventionChloroquine sulphate msdsHydroxychloroquine dosingHydroxychloroquine mnemonic People who have sickle cell disease have abnormal hemoglobin, called hemoglobin S or sickle hemoglobin, in their red blood cells. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. People who have sickle cell disease inherit two abnormal hemoglobin genes, one from each parent. Sickle Cell Disease National Heart, Lung, and Blood.. Learn More About Sickle Cell Disease CDC. Sickle cell disease.. Plaquenil is used to treat or prevent malaria and to treat the symptoms of rheumatoid arthritis. Learn about side effects, interactions and indications. Skip to Content Sickle cell disease SCD is a group of inherited red blood cell disorders. If you have SCD, there is a problem with your hemoglobin. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. With SCD, the hemoglobin forms into stiff rods within the red blood cells. Sickle cell disease can be diagnosed in an unborn baby by sampling some of the fluid surrounding the baby in the mother's womb amniotic fluid. If you or your partner has sickle cell anemia or the sickle cell trait, ask your doctor about this screening.