Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Sulfasalazine and hydroxychloroquine rheumatoid arthritis How dangerous is hydroxychloroquine How to test chloroquine drug Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America. Clinical depression may be brought about by lupus, by the various medications used to treat lupus, and/or by any of the factors and forces in a person’s life that are not related to lupus. For reasons that are not entirely understood, people with chronic disease often experience this type of depression. Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Plaquenil and depression Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Lupus and depression Know the signs and how to get help. Quit plaquenil breast cancer treatmentsHow long should i take plaquenilChloroquine uk pharmacyDoes plaquenil cause low wbc Major Depression is #139 concern in Plaquenil discussions. Plaquenil is an arthritis medication and an anti infectious agent. Uses Plaquenil is prescribed for Lupus, RA, Sjogren's Syndrome and Joint Pain and is mostly mentioned together with these indications. Can Plaquenil cause Major Depression? - Treato. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Plaquenil, anxiety and depression,. Hi! I think Plaquenil is the cause of my extreme fatigue too. I am not anemic at this time and I get exhausted just trying to get through the day. I have also been on Plaquenil about three months. All of my arthritis swelling and pain are gone, but the fatigue will not let up! Hope things change for you. Anxiety, depression and suicidal ideation in patients with rheumatoid arthritis in use of methotrexate, hydroxychloroquine, leflunomide and biological drugs. Pinho de Oliveira Ribeiro N1, Rafael de Mello Schier A, Ornelas AC, Pinho de Oliveira CM, Nardi AE, Silva AC. Sickmama - so very sorry to hear about your worsening moods and depression/anxiety. I can only speak for myself and my personal experience. Plaquenil has helped me on many levels on many days. I think, for me, anyway, the depression and anxiety I often feel is due to the autoimmune issues/sjogrens.