These, as well as other commonly used medications, can cause various types of allergic reactions that frequently lead to hyperpigmentation (dark patches). There are four primary types of medication reactions that can lead to often troubling and disfiguring hyperpigmentation: A fixed drug eruption is a round, dark patch or eruption that results from a reaction to a drug (usually a prescription medication). Osteoarthritis joint nodules hydroxychloroquine Chloroquine prescribing information Are you more likely to get sick while take hydroxychloroquine Plaquenil 200 mg price uk Some medications, such as plaquenil and minocycline, can cause permanent dark skin plaques, which resemble black and blue marks similar to morphea scleroderma. Cosmetically, pigmentation differences can be covered up with corrective cosmetics, such as Dermablend. Drug-Induced Hyperpigmentation caused by Minocycline Minocin Antibiotic Skin figure 1A,B. There was no pigmentation at other body sites. Biopsy from the plaque showed necrobiotic collagen with intradermal mucin and perivascular lymphohistiocytic infiltrate accom-panied by brown coarse pigment in the dermis figure 1C,D. The pigment was negative on Perl’s stain figure 1E. This was a unique pattern of Deposits in these cells can lead to cutaneous pigmentation and possibly retinal toxicity. Hydroxychloroquine breaks down into two pharmacologically active metabolites — desethyl-hydroxychloroquine and desethyl-chloroquine. After a single dose, hydroxychloroquine is excreted mainly in the faeces, and only 20% is excreted unchanged in the urine. The round patch is usually fixed to one spot will appear in this same location within 24 hours of each dose taken. This type of reaction leaves a grey-blue, round patch on the skin. Hydroxychloroquine skin pigmentation Skin Discoloration and Plaquenil - Arthritis Information, Hydroxychloroquine induced cutaneous pigmentation a unique. Opthalmologist baseline test for plaquenil bethlehem Home August 2013 - Volume 19 - Issue 5 Hydroxychloroquine-Induced Hyperpigmentation. Log in to view full text. If you're not a subscriber, you can Hydroxychloroquine-Induced Hyperpigmentation JCR Journal.. Hydroxychloroquine DermNet NZ. Plaquenil and spots on skin DailyStrength. Purpose Hydroxychloroquine HCQ is a systemic antimalarial used to treat cutaneous and systemic lupus erythematosus and other connective tissue diseases. Mucocutaneous hyperpigmentation is a well-documented side effect of HCQ that occurs in 10-25% of users. Lesions resemble ecchymoses that fail to resolve, and drug extravasation and binding to melanin is a theorized mechanism. Some cases are. Hydroxychloroquine. What is Hydroxychloroquine? Hydroxychloroquine is an anti-malarial drug that is used to treat a wide variety of skin conditions. The way in which it works is unknown but it is understood to have anti-inflammatory effects. What is Hydroxychloroquine used for? MAIN OUTCOMES AND MEASURES The primary outcome was the clinical features of HCQ-induced pigmentation. Skin biopsies were performed on 5 patients, both in healthy skin and in the pigmented lesions. The statistical associations of HCQ-induced pigmentation with several variables were calculated using univariate and multivariate analyses.