Chloroquine resistant malaria drug

Discussion in 'Cheap Chloroquine' started by artk, 26-Feb-2020.

  1. Virt13 User

    Chloroquine resistant malaria drug


    Rapid diagnostic assays for Pf CRT mutations are already employed as surveillance tools for drug resistance. Here, we review recent field studies that support the central role of Pf CRT mutations in chloroquine resistance.

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    Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a multigenic basis of resistance. Sep 15, 2001 Searches for new drugs against chloroquine-resistant malaria, especially as they relate to analogues of chloroquine and chemosensitizing agents against the different forms of P. falciparum and P. vivax, should benefit greatly from research work in this area Chloroquine phosphate. Chloroquine is the preferred treatment for any parasite that is sensitive to the drug. But in many parts of the world, the parasites that cause malaria are resistant to chloroquine, and the drug is no longer an effective treatment. Other common antimalarial drugs include Combination of atovaquone and proguanil Malarone

    Recognition of the value of chloroquine was delayed, and it was not brought forward until it was reevaluated in the United States and designated the drug of choice against malaria near the end of World War II [3]. These studies suggest chloroquine resistance arose in ⩾4 distinct geographic foci and substantiate an important role of immunity in the outcomes of resistant infections after chloroquine treatment. Investigation of the resistance mechanisms and of the role of immunity in therapeutic outcomes will support new approaches to drugs that can take the place of chloroquine or augment its efficiency Early in the 20th century, intense demands for an effective quinine substitute launched the discovery and evaluation of a series of organic compounds (beginning with methylene blue), which led to pamaquine and quinacrine after World War I and ultimately produced chloroquine in 1934 [1, 2].

    Chloroquine resistant malaria drug

    Chloroquine - Wikipedia, Chloroquine-Resistant Malaria The Journal of Infectious.

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  3. Petersen, I. et al. Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter. Mol. Microbiol. 97, 381–395 2015.

    • Drug resistance in Plasmodium Nature Reviews Microbiology.
    • Malaria - Diagnosis and treatment - Mayo Clinic.
    • Chloroquine Indications, Side Effects, Warnings -.

    Chloroquine was first discovered in the 1930s in Germany and began to be widely used as an anti-malaria post-World War II, in the late 1940s. However, resistance to the drug also rapidly emerged, with the first cases of Plasmodium falciparum not being cured by administration of chloroquine being reported in the 1950s. Chloroquine-Sensitive Zones. Chloroquine is the drug of choice for travel to areas where chloroquine resistance has not been described. Chloroquine is active against the erythrocytic forms Fig. 6.3 of sensitive strains of all species of malaria, and it is also gametocidal against P. vivax, P. malariae, and P. ovale. Malaria patients who do not respond to chloroquine treatment should be switched to a regimen recommended for chloroquine-resistant P. falciparum e.g. atovaquone/proguanil, artemether/lumefantrine, regimen of quinine in conjunction with doxycycline, tetracycline, or clindamycin or chloroquine-resistant P. vivax e.g. quinine and doxycycline or tetracycline in conjunction with primaquine, atovaquone/proguanil in conjunction with primaquine, mefloquine in conjunction with primaquine. 143

     
  4. 1artes1 New Member

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  5. Statist XenForo Moderator

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  6. Fyold56 XenForo Moderator

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