I'm not completely pain free, but it's a lot better than it was. I've been on plaquenil since mid June I have had a lot of stress in my life so I can't determine what is causing what. Not seeing any improvements with pain but I just went to 0 prednisone 3 weeks ago. said give it a few months and if I don't see any improvement I might as well go off of it. Wanted to let you know that I was on plaquenil for about three years and I told my RA doctor that my fatigue was worse. It just seems like the fatigue is worse than it has ever been, and it doesn't seem to matter if I go to bed early or take a nap during the day. Woke up and cleaned the kitchen an hour later(my kitchen is a galley kitchen 8 ft maybe.no time) Took a nap. Early on I did get those stomach cramps and diarrhea. All my pain is tolerable and he sees no deformities so he says he doesn't see RA activity. Just because the pain is tolerable doesn't make me like it any better. He did a plaquenil test and sure enough it was low. Hydroxychloroquine warnings What can happen if you stop taking plaquenil Chloroquine diphosphate 25 μm 10-2 visual field test plaquenil Apr 17, 2014 I completely agree with Lynnwood that plaquenil helps stop the progression of your disease, so the longer you wait the worse your Sjogren's becomes. Plaquenil is a fairly benign medication and was originally developed to protect against malaria. Later it was found to help autoimmune diseases. It can be months before you get relief with plaquenil. Fatigue Fatigue is most effectively managed with self-care measures and exercise. Exercise provides similar benefit to reduce fatigue in Sjögren’s patients as was seen for those with RA, SLE or Multiple Sclerosis. Systemic Manifestations in Sjögren’s Patients Aug 09, 2016 Sjögrens fatigue – and all autoimmune fatigue – is a clinical conundrum. No one really knows the cause, although there is some interesting research being done by a neuroscientist in Alabama who may shed some light on the underlying cause soon. Fatigue is unrelated to blood tests e.g.- sed rate. I wake up tired in the morning, get my kids fed and off to the schoolbus, and some days that's all I can do until it's time to go pick them up and make dinner, then I collapse after the kids are put to bed. I don't know if this is just the way RA is, or if it is a side effect of the medicine. Wasn't going to eat luch because I would have to move to do it.husband bought out. Kids came home, helped with homewrok, made dinner..picked up couch(because my blanket and pillow were there) Went to bed at 9. Plaquenil sjogren's fatigue Primary Sjögren’s syndrome too dry and too tired., Sjögren’s Systemic Manifestations in Sjögren’s Patients. Sub for plaquenilPlaquenil visual side effects Fatigue is part of malaria, which is the normal use of this medication. Here are the side effects be sure your doctor looks at this. Get emergency medical help if you have any of these signs of an allergic reaction while taking hydroxychloroquine hives ; difficulty breathing; swelling of your face, lips, tongue, or throat. Hydroxychloroquine - thigh muscle weakness?. Sjögrens Fatigue – an Autoimmune Conundrum! SjögrensLife. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Jun 21, 2016 Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. I started on Plaquenil again. I stopped taking it the first time because my stomach hurt so bad. My rheumy said to just take a half a pill right now 100 mg. It's been about a week now and I am noticing dizziness, fatigue and just kind of weak. Can this be a side effect of Plaquenil when you first start? I don't recall it happening last time. It’s used in people with Sjogren’s syndrome, rheumatoid arthritis, and lupus to relieve joint pain, fatigue, and rashes. It may take up to 12 weeks for you to notice the effects of hydroxychloroquine. Hydroxychloroquine is safe, even for pregnant women with Sjogren’s syndrome.