The most commonly used DMARD is methotrexate (Trexall®, Rheumatrex®, Otrexup®, Resuvo®). Other DMARDs include sulfasalazine (Azulfidine®), leflunomide (Arava®), hydroxychloroquine (Plaquenil®), Cyclosporine (Neoral®, Sandimmune®), Azathioprine (Imuran®), and Apremilast (Otezla®). Extraerythrocytic malria and chloroquine Plaquenil and weight gain forum How does plaquenil treat arthritis Hydroxychloroquine related rash on external genitalia Conventional DMARDs that have been paired with methotrexate include sulfasalazine, hydroxychloroquine, cyclosporine, leflunomide and azathioprine. Although studies of these combinations have shown differing levels of benefit, the combinations of methotrexate plus leflunomide and methotrexate plus sulfasalazine are among the most effective. Rheumatoid arthritis is a chronic disorder for which there is no known cure. Fortunately in the last few years, a shift in strategy toward the earlier institution of disease modifying drugs and the availability of new classes of medications have greatly improved the outcomes that can be expected by most patients. Traditional DMARDs Methotrexate, Leflunomide, Sulfasalazine, Hydroxychloroquine, and Combination Therapies Amy C. Cannella, James R. O’dell Key Points Methotrexate is one of the most durable and frequently used disease-modifying antirheumatic drugs DMARDs in monotherapy as well as the cornerstone of combination therapy for rheumatoid. This prevents some cells in your body from reproducing themselves. Methotrexate works by blocking enzymes that help DNA (genetic material in the cells of your body) form or repair. Leflunomide methotrexate and hydroxychloroquine Is Leflunomide as Safe and Effective in the Treatment of Rheumatoid., Rheumatoid Arthritis Treatment Options Johns Hopkins Arthritis Center Can you take lyrica with plaquenilCan plaquenil cause stomach and esophagus problems I am going to have to decide in October whether to start methotrexate or arava. I currently take plaquenil, prednisone and piroxicam for my RA. I've read quite a bit on both drugs. My doctor seems to think I would need only a low dose of methotrexate to get it under control. Methotrexate or Arava? -. Traditional DMARDs Methotrexate, Leflunomide, Sulfasalazine.. Anxiety, depression and suicidal ideation in patients with.. Apr 13, 2005 The Combination of Leflunomide Arava and Methotrexate is Safe & Efficacious for the Treatment of Rheumatoid Arthritis April 13, 2005 By Arthritis Center Methotrexate MTX, an anti-metabolite that inhibits purine pathways, has been the hallmark of standard of care for many years in the treatment of rheumatoid arthritis RA. Fuerst and co-workers noted the risk of postoperative wound healing complications in patients undergoing leflunomide therapy was significantly higher than in patients undergoing alternative treatments with methotrexate.17 These authors reported a 40.6 percent complication rate in patients undergoing leflunomide therapy in comparison to a 13.6. After 2 years of taking MTX, Sulfasalazine and Hydroxychloroquine in combination my new Rheumy has determined that there aren't having enough effect as a combination and wants to take me off the Sulfa and substitute Leflunomide.