If I take everything I have to take all at once I am so sick, worse than the normal sarc sick. I have no problems, but I also take a probiotic each day. I take most of my meds spaced out through the day (4x per day now down from 6x) and with food in order to minimize the side effects and get the junk in me. I'm hoping to stop this med over the summer it kills my stomach .. Scleroderma plaquenil Block mhc chloroquine The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. I am starting to wonder if they are related to Plaquenil. My doctor now wants me to start on Chloroquine instead of plaquenil. I've always been one to go for the natural route and am starting to feel like I should just stop taking everything and see what happens - so frustrating. You take plaquenil twice a day, approximately 12 hours apart. The most common side effect is mild nausea and occasional stomach cramps. You can take it with food if it upsets your stomach. You should also have a complete eye exam before starting this medication and then every 6 months. Michele I have to take mine separate and each time with food. Otherwise they make me really sick and nauseous too. I'm supposed to only have a mild case of sarc ... Should you take plaquenil in the am or pm Plaquenil oral Reviews and User Ratings Effectiveness., Plaqunil rash - Oct mac plaquenil saucer Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Best time to take plaquenil - HealthBoards. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. If you miss a dose, take it as soon as you remember. If it is very near the time of the next dose, skip the missed dose and continue with your normal dosing schedule. Do not double dose at one time to catch up. Plaquenil should be stored away from light and moisture and at room temperature up to 86 degrees F 30 degrees C. Definitely take it with food, and be aware that in the beginning it can cause weird, intense dreams.you might want to take it in the morning in order to offset that a bit. Once your body gets used to it, you should be okay taking it at night or whenever, as long as there is food in your tummy. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage.