Pregnant women and chloroquine

Discussion in 'Canadian Pharmacies Online' started by -=Natali=-, 16-Mar-2020.

  1. andrew-kornev New Member

    Pregnant women and chloroquine

    While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta.

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    Chloroquine has not been formally assigned to a pregnancy category by the FDA. There are no controlled data in human pregnancies. Congenital anomalies were reported in the offspring of one woman being treated with chloroquine 250 to 500 mg daily during pregnancy for SLE; however, chloroquine has been used in the prophylaxis and treatment of malaria during pregnancy without evidence of fetal harm. Treatment for uncomplicated malaria where the above signs are absent in pregnant women is usually chloroquine for P. vivax, P. ovale, P. knowlesi and P. malariae, as well as for P. falciparum if there are no reports of this parasite being resistant to chloroquine For pregnant women diagnosed with uncomplicated malaria caused by chloroquine-resistant P. falciparum infection, women in the second and third trimesters can be treated with artemether-lumfantrine, and for all trimesters, mefloquine or a combination of quinine sulfate and clindamycin is recommended. Quinine treatment should continue for 7 days for infections acquired in Southeast Asia and for 3 days for infections acquired elsewhere; clindamycin treatment should continue for 7 days.

    Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area.

    Pregnant women and chloroquine

    Aralen, Chloroquine phosphate chloroquine dosing., Antimalarial Drugs During pPregnancy –

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  5. Dosages Chloroquine 1,500 mg base over 3 days twice during pregnancy or Chloroquine 600 mg loading dose followed by 300 mg orally once per week. Intermittant preventative treatment in pregnancy IPTp doses will be administered between weeks 20-28 and weeks 28-34 gestation, 4 weeks apart.

    • Chloroquine for Malaria in Pregnancy - Full Text View..
    • Treatment of Malaria Guidelines For Clinicians United..
    • Hydroxychloroquine Use During Pregnancy.

    One of the major challenges of the current Zika virus ZIKV epidemic is to prevent congenital foetal abnormalities, including microcephaly, following ZIKV infection of pregnant women. Given the urgent need for ZIKV prophylaxis and treatment, repurposing of approved drugs appears to be a viable and immediate solution. A baby’s body and most internal organs are formed during the first 12 weeks of pregnancy. It is mainly during this time that some medicines are known to cause birth defects. There is currently no scientific evidence to suggest that women who take chloroquine in pregnancy have a higher chance of having a baby with a birth defect. Pregnancy did not significantly affect blood concentrations of chloroquine or its metabolite, desethylchloroquine, in women with P. vivax malaria.

  6. Lash_Z Well-Known Member

    Benefits include even better soft lens searches and helpful contact lens calculators (including RGPs and cross cylinders). New Guidelines on Hydroxychloroquine Dosage - Where Are We. ACR Actual-weight hydroxychloroquine dosing works in SLE. RheumNow Hydroxychloroquine Blood Levels in SLE MedPage Today
  7. searchwizard Moderator

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