Aralen mechanism of action

Discussion in 'Canadian Pharmaceuticals Online' started by web-cru, 06-Mar-2020.

  1. maxim_625 Guest

    Aralen mechanism of action

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. Find information on Chloroquine Aralen in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. The mechanism of resistance involves a reduced accumulation of the drug, although again the mechanism involved is controversial. Possible explanations include an energy-dependent efflux of preaccumulated drug via an unidentified transmembrane protein pump, or an increase in vacuolar pH such that the proton gradient responsible for drug concentration is reduced.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Aralen mechanism of action

    CHLOROQUINE PHOSPHATE, USP, Chloroquine Aralen Davis’s Drug Guide

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  5. ARALEN® Sanofi. Chloroquine Phosphate. Antimalarial – Antiparasitic. Action And Clinical Pharmacology Chloroquine has been found to be highly active against the erythrocytic forms of Plasmodium vivax, ovale and malariae and many strains of Plasmodium falciparum but not the gametocytes of Plasmodium falciparum.

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    SELECTED DRUGS AND THEIR MECHANISMS OF ACTION Generic Name Brand Name Class of Drug Mechanism of Action Chloroquin Aralen Antimalarial Inhibits protein synthesis by inhibiting DNA and RNA polymerase Cimetidine Tagamet H 2 receptor antagonist Blocks H 2 receptor and reduces secretion of Apr 02, 2019 Aralen chloroquine phosphate is an antimalarial drug used to treat and to prevent malaria. It is also used to treat infections caused by amoebae. Aralen is available in generic form. Common side effects of Aralen include blurred vision, nausea, vomiting, abdominal or stomach cramps, headache, diarrhea, temporary hair loss, changes in hair. Mechanism of Action Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part, from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain.

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  7. krizis User

    Hydroxychloroquine Oral Route Proper Use - Mayo Clinic However, dose is usually not more than 800 mg for the first dose and not more than 400 mg for the next doses. For treatment of arthritis Adults—At first, 400 to 600 milligrams mg taken as a single dose or in two divided doses once a day. Then, 200 to 400 mg taken as a single dose or in two divided doses once a day.

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