Chloroquine stability in water

Discussion in 'Canadian Pharcharmy' started by darkdw, 20-Mar-2020.

  1. LDJ Well-Known Member

    Chloroquine stability in water


    The effects of light at wavelengths of 240–600 nm on solutions of chloroquine in isopropanol, and of light at wavelenghts of 320–600 nm on solutions of chloroquine in buffer solutions were investigated. Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it.

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    Oct 30, 2019 Hydroxychloroquine can be detected in the cord blood at delivery in concentrations similar to those in the maternal serum Costedoat-Chalumeau 2002. In animal reproduction studies with chloroquine, accumulation in fetal ocular tissues was observed and remained for several months following drug elimination from the rest of the body. Chloroquine CAS NO.54-05-7 is stability stable, but light sensitive. It is incompatible with strong oxidizing agents. It is soluble in water, insoluble in alcohol, chloroform and ether. Chloroquine is a lysosomotropic agent that prevents endosomal acidification 1. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes.

    It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance.

    Chloroquine stability in water

    Chloroquine - DrugFuture, Chloroquine supplier CasNO.54-05-7

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  5. Chloramines in Drinking Water. Chloramines also known as secondary disinfection are disinfectants used to treat drinking water and they Are most commonly formed when ammonia is added to chlorine to treat drinking water. Provide longer-lasting disinfection as the as the water moves through pipes to consumers.

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    Deoxoartelinic acid also showed remarkable stability with a half-life of 258.66 h, 23 times more stable than clinically useful arteether in simulated stomach acid, and improved solubility, 4 times more soluble than artemisinin in water. Samples of different dosage forms of chloroquine phosphate, that covered the 23 excipents used in chloroquine phosphate formulation were analyzed by dissolving a quantity equivalent to 100 mg of chloroquine phosphate of each formulation in 100 ml of water, 5 ml of this solution was diluted to 100 ml with water, the International Journal of Pharmaceutics, 72 1991 11-18 1991 Elsevier Science Publishers B. V. 0378-5173/91/$03.50 ADONIS 0378517391002014 UP 02399 11 Photochemical stability of biologically active compounds. IV, Photochemical degradation of chloroquine Karin Nord, Jan Karlsen and Hanne Hjorth Tnesen Institute of Pharmacy, Department of.

     
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    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center Plaquenil Uses, Dosage & Side Effects - Protecting your eyesight when taking Plaquenil Lupus Foundation of.
     
  7. ardor XenForo Moderator

    Nortriptyline oral and chloroquine Drug Interactions - RxList Learn about drug interactions between nortriptyline oral and chloroquine and use the RxList drug interaction checker to check drug combinations.