Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. How does hydroxychloroquine treat lupus Chloroquine peak plasma concentraion A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of. Since the pivotal trial evaluating the effect of temozolomide TMZ, overall survival has not increased. Treatment of GBM xenografts in vivo with chloroquine CQ, an antimalarial agent, has been shown to reduce the hypoxic fraction and sensitizes tumors to radiation. Chloroquine is in trials as an antiretroviral for HIV-1/AIDS and is being considered in pre-clinical models as a potential agent against chikungunya fever. 44 Other edit The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine clinical trials glioma Immunotherapy for Glioblastoma MD Anderson Cancer Center, The Addition of Chloroquine to Chemoradiation for. Plaquenil lower plateletsPlaquenil and breastfeeding lupus Chloroquine CQ is a potent autophagy blocker and is the most widely investigated substance in this context. Previously, the effect of CQ has been demonstrated in a small randomized controlled trial in GBM treated with radiotherapy and carmustine. The Addition of Chloroquine to Chemoradiation for Glioblastoma,. Chloroquine - Wikipedia. Re-purposing Chloroquine for Glioblastoma Potential Merits.. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers. Chloroquine, in conjunction with other treatments, may prolong survival in patients with glioblastoma multiforme. Larger clinical trials are needed. —The Editors Article Chloroquine for Glioblastoma Multiforme 338 7 March 2006 Annals of Internal Medicine Volume 144 • Number 5 Chloroquine is a strong lysosomotropic and DNA-intercalating agent in experimental studies Neurosurgical Focus 142 February, 2003 and an open-label clinical trial the investigators have demonstrated a strong adjuvant effect of chloroquine on the therapy of malignant gliomas.