Hydroxychloroquine (Plaquenil®) has received little attention in Crohn’s disease (CD). Many anti-inflammatory medications used for rheumatoid arthritis have been applied to inflammatory bowel disease (IBD) therapy. Plaquenil and low dose naltrexone Chloroquine physical properties Chloroquine prophylaxis Many anti-inflammatory medications used for rheumatoid arthritis have been applied to inflammatory bowel disease IBD therapy. Hydroxychloroquine Plaquenil® has received little attention in Crohn’s disease CD. 1 This anti-malarial agent is an older disease-modifying anti-rheumatic drug and is used by rheumatologists for patients who try and fail or fear trying immunomodulator and biologic therapy. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur. Hydroxychloroquine Plaquenil is a drug that is classified as an anti-malarial drug. Plaquenil is prescribed for the treatment or prevention of malaria. It is also prescribed for the treatment of rheumatoid arthritis, lupus, and the side effects of lupus such as hair loss, joint pain, and more. Furthermore it has remained effective for a number of patients for many years (Personal Communication, Lloyd Mayers, MD, 2010). The mechanism of actions that might apply to IBD includes inhibition of T-cells and intracellular stabilization of intracellular inflammation and the immune cascade. Plaquenil and intestinal problems Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, Plaquenil Side Effects Common, Severe, Long Term - Plaquenil cause high blood pressurePlaquenil discontinuedChloroquine sulphate structureCan you take plaquenil and viagra together Inflammatory bowel disease is the term used to describe two conditions Chrohn’s disease CD and ulcerative colitis UC. These conditions are caused by chronic inflammation in parts of the gastrointestinal tract GI that includes the mouth, esophagus that connects the throat and the stomach, stomach, small intestine, large intestine and anus. Inflammatory Bowel Disease Arthritis Foundation. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. Increasing plaquenil, having problems. As Kathy said, the Plaquenil can take several months to kick in. I am no physician, but it is my understanding that one of the side effects of Plaquenil can be digestive problems such as you describe. Try to eat some plain crackers and drink a little ginger ale. Club soda with lime is another alternative. Hydroxychloroquine Plaquenil® has received little attention in Crohn’s disease CD. 1 This anti-malarial agent is an older disease-modifying anti-rheumatic drug and is used by rheumatologists for patients who try and fail or fear trying immunomodulator and biologic therapy. People often have some intestinal issues when first starting plaquenil - things generally settle down in a few days. If the issue persists over 10 days call your Dr. Also, it's good to have at least a few bites of food with it.