Prednisone and plaquenil during pregnancy

Discussion in 'Canadian Drugs' started by Anturage, 05-Mar-2020.

  1. MikhailMikhail Well-Known Member

    Prednisone and plaquenil during pregnancy

    -The short-term use of corticosteroids antepartum for the prevention of respiratory distress syndrome does not seem to pose a risk to the fetus or newborn infant. Teratogenicity including increased incidence of cleft palate have occurred in animal studies.

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    Experts say pregnant women can safely take the steroid prednisone during the second and third trimester of pregnancy and while breastfeeding. Experts also consider Plaquenil hydroxychloroquine. The continuation of medications for SLE during pregnancy helps to prevent SLE flares. Many women with SLE will be taking hydroxychloroquine HCQ Plaquenil prior to pregnancy. This medication has been proven to decrease the risk of SLE flare, improve the prognosis of SLE nephritis, and prevent death. I’ve been on Plaquenil for 6 months and am currently 11 weeks pregnant. I’ve had no side effects from it but do get my eyes checked due to possible retinal damage very rare from the Plaquenil. Unfortunately for me it hasn’t worked exceptionally well and I’ve been in a terrible flare.

    Reduced placental and birth weight have been recorded in animals and humans after long term treatment. A number of cohort and case controlled studies in humans suggest maternal corticosteroid use in the first trimester produces a slight increased risk of cleft lip with or without cleft palate (increased from 1 out of 1000 to 3 to 5 out of 1000 infants).

    Prednisone and plaquenil during pregnancy

    Prednisone Use During Pregnancy, Lupus Activity in Pregnancy - PubMed Central PMC

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  7. Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. This drug should only be used during pregnancy if the potential benefit justifies the potential risk.

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    Plaquenil hydroxychloroquine has a good safety record in lupus pregnancy, and is usually continued if needed to control maternal lupus. Management and Monitoring Lupus pregnancy should be timed to coincide with a period of good disease control if at all possible. Prednisone is largely metabolized by the placenta, and is unlikely to cause any fetal malformations, but will increase the risk of diabetes and hypertension in the mother. Some immunosuppressives, such as imuran azathioprine have been continued during lupus pregnancy when necessary to control maternal lupus. Research has looked into the risks of prednisone during pregnancy, and in some studies, the small risk seen in general was not as great in women taking prednisone for IBD. Oral Clefts There is a very small risk of a cleft lip or palate in babies born to women who take prednisone during pregnancy, in particular when the prednisone is taken in.

  8. Infomedia User

    The 4-aminoquinoline drug hydroxychloroquine (HCQ) is reported to be as active as chloroquine (CQ) against falciparum malaria, and less toxic. ACD A-Z of Skin - Hydroxychloroquine Coming off Hydroxychloroquine I went to see my rheumy. - NRAS Low-Dose Hydroxychloroquine is as Effective as Phlebotomy in.
  9. Oleant New Member

    Solar urticaria as the presenting manifestation of. Full text Full text is available as a scanned copy of the original print version. Get a printable copy PDF file of the complete article 1.2M, or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.

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