Chloroquine in cancer therapy a double edged sword of autophagy

Discussion in 'Canadian Drugs' started by Musulunger, 04-Mar-2020.

  1. asker123 Well-Known Member

    Chloroquine in cancer therapy a double edged sword of autophagy


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    In particular, the autophagy inhibitors chloroquine and hydroxychloroquine, commonly used antimalarial drugs, are currently being investigated in phase I and phase II trials in patients with glioblastoma and myeloma. 6 In other studies, treatment of various cancer cells with small-molecule autophagy inhibitors, such as 3-methyladenine. Correction Chloroquine in Cancer Therapy A Double-Edged Sword of Autophagy Cancer Res February 15 2013 73 4 1446; DOI 10.1158/0008-5472. CAN-13-0041 Share This Article Copy There is a growing evidence that antimalarial chloroquine could be re-purposed for cancer treatment. A dozen of clinical trials have been initiated within the past 10 years to test the potential of chloroquine as an adjuvant treatment for therapy–refractory cancers including glioblastoma, one of the most aggressive human cancers.

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    Chloroquine in cancer therapy a double edged sword of autophagy

    Dual Targeting of Autophagy and MEK in KRAS Mutant Cancer., Correction Chloroquine in Cancer Therapy A Double-Edged.

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  3. Herein, we report results of administration of rapamycin, a specific inhibitor of the mechanistic target of rapamycin mTOR signaling pathway, and chloroquine, a lysosomal inhibitor which reverses autophagy by accumulating in lysosomes, responsible for blocking autophagy in 20-month old VCPR155H/+ mice.

    • Rapamycin and Chloroquine The In Vitro and In Vivo Effects..
    • Frontiers Re-purposing Chloroquine for Glioblastoma..
    • Autophagy in Health and Disease A Double-Edged Sword.

    Apr 13, 2009 Therefore, it is difficult to predict if inhibition of autophagy may sensitise resistant tumour cells to cytotoxic therapy. Fact is that autophagy plays a dual role in cancer. Our actual examinations suggest a basal enhanced level of autophagy in highly resistant cancer cells, which might promote growth and therapy resistance. Autophagy Blockade via Chloroquine CQ or Hydroxychloroquine HCQ Enhances the. Kimura, al.2013 Chloroquine in cancer therapy a double-edged sword of autophagy. Cancer Res.73, 3–7 6. Onorati, A. V. et al. 2018 Targeting autophagy in cancer. Cancer 124, 3307–3318 7. Lee, C. S. et al. 2019 MAP kinase and autophagy path-ways. Dec 29, 2015 Autophagy is a highly conservative cell behavior to keep the intracellular homeostasis and is frequently activated when cells encounter disgusting conditions, such as nutrition or growth factor deprive, hypoxia and cytotoxic agents. However, the precise role of autophagy under various conditions may be opposite, differ from protect cells survival to promote cells death, and the mechanism of.

     
  4. quanzo New Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Pharmacokinetics and Toxicity in Rats and Monkeys of coDbait. Changes in Some Pharmacokinetics Parameters of Chloroquine. Pharmacokinetics of the Antimalarial Drug, AQ-13, in Rats and.
     
  5. svtroica New Member

    The resource you are looking for (or one of its dependencies) could have been removed, had its name changed, or is temporarily unavailable. Hydroxychloroquine - Wikipedia Hydroxychloroquine Oral Route Side Effects - Mayo Clinic Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs.
     
  6. ddff Well-Known Member

    Atovaquone - Wikipedia Uses. Atovaquone is a medication used to treat or prevent For pneumocystis pneumonia PCP, it is used in mild cases, although it is not approved for treatment of severe cases.

    Chloroquine hydrochloride - GLOWM
     
  7. skor88 Well-Known Member

    Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Feb 19, 2020 Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days.

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